Abstract

Background: The prevalence of GDM is reported to vary widely from 3.8 to 21% in different parts of India depending on the geographical location. Objectives of this study was to find the relation of GDM with overweight and obesity.

Material & Methods: A study on the prevalence and possible risk factors associated with gestational diabetes was undertaken on 100 mothers between the age group of 20 and 35 years; among pregnant women recruited from Gynecology and Obstrectics outpatient of S.M.S Medical College, Jaipur, Rajasthan from January 2016 to January 2017. In this study 100 women were divided in two groups, Group I (n=50) were control group (non gestational diabetic) and Group II (n=50) was study group (gestational diabetic).

Results: In present study maximum subjects 35 (70%) seen in control group and 31 (62%) in study group in 25-32 years of age group. The maximum women (n=31) were normal weight (BMI=18.5-24.9 kg/m2) in control group and in study group 27 women were normal weight (BMI=18.5-24.9 kg/m2), followed by 18 women were over-weight (BMI=25-29.9 kg/m2). Body mass index ≥ 25 was significantly higher (p= 0.033*) in cases than controls (44% vs. 22%).

Conclusion: Our study showed that overweight and obese women with more than 25 years of age were more prone to develop GDM. We recommend that health authorities strengthen maternal health programs by focusing on the prevention and control of modifiable risk factors during the pre-pregnancy period.

Keywords: Gestational diabetes mellitus (GDM), BMI, Pregnant Women, Overweight.

1.      Expert committee on the diagnosis and classification of diabetes mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus.  Diabetes Care. 2003;26:S5–20.

2.      American Diabetes Association. Gestati-onal diabetes mellitus (Position Statem-ent) Diabetes Care.2004;27:S88–90. 

3.      Diagnosis and classification of diabetes mellitus: American Diabetes Association Diabetes Care. 2013;36:4–5.

4.      Unwin N, Whiting D, Guariguata L, Ghyoot G, Gan D, editors. 5th ed. Brussels: International Diabetes Feder-ation; 2011. International Diabetes Federation, Diabetes Atlas; pp. 11–74.

5.      Anjana RM, Pradeepa R, Deepa M, Datta M, Sudha V, Unnikrishnan R, et al. ICMR-INDIAB Collaborative Study Group. Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: Phase I results of the Indian Council of Medical research-India Diabetes (ICMR-INDIAB) study. Diabetologia. 2011;54:3022–7. 

6.      Abate N, Chandalia M. Ethnicity, type 2 diabetes and migrant Asian Indians. Indian J Med Res.2007;125:251–8.

7.      Seshiah V, Balaji V, Balaji MS, Panneerselvam A, Kapur A. Pregnancy and diabetes scenario around the world. Int J Gynaecol Obstet. 2009;104:S35–8.

8.      Dang K, Homko C, Reece EA. Factors associated with fetal macrosomia in offspring of gestational diabetic women. J Matern Fetal Med. 2000;9:114–7.

9.      K Sreekanthan, A Belicita, K Rajendran, Anil Vijayakumar. Prevalence of Gestational Diabetes Mellitus in a Medical College in South India: A Pilot Study. Indian Journal of Clinical Practice, Vol. 25, No. 4, September 2014.

10.  Weight Gain during pregnancy. Committee Opinion No. 549. American college of obsteticians and gynecologists.  Obstet Gynecol. 2013;121:120–2.

11.  Kale SD, Kulkarni SR, Lubree HG, Meenakumari K, Deshpande VU, Rege SS, et al. Characteristics of gestational diabetic mothers and their babies in an Indian diabetes clinic. J Assoc Physicians India. 2005;53:857–63.

12.  Albareda M, Caballero A, Badell G, Piquer S, Ortiz A, de Leiva A, et al. Diabetes and abnormal glucose tolerance in women with previous gestational diab-etes. Diabetes Care. 2003;26:1199–205. 

13.  Hadaegh F, Tohidi M, Harati H, Kheirandish M, Rahimi S. Prevalence of gestational diabetes mellitus in southern Iran (Bandar Abbas City) Endocr Pract. 2005;11:313–8. 

14.  Siribaddana SH, Deshabandu R, Rajapakse D, Silva K, Fernando DJ. The prevalence of gestational diabetes in a Sri Lankan antenatal clinic. Ceylon Med J. 1998;43:88–91.

15.  Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346(6):393–403.

16.  Zhang C, Solomon CG, Manson JE, Hu FB. A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus. Arch Intern Med. 2006;166(5):543–548.

17.  Zhang C, Liu S, Solomon CG, Hu FB. Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus. Diabetes Care. 2006;29 (10):2223–2230.

18.  Artal R, Catanzaro RB, Gavard JA, Mostello DJ, Friganza JC. A lifestyle intervention of weight-gain restriction: diet and exercise in obese women with gestational diabetes mellitus. Appl Physiol Nutr Metab. 2007;32(3):596–601. 

19.  Chu SY, Callaghan WM, Kim SY, et al. Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care. 2007;30 (8):2070–2076.