Abstract

Background: Hypertensive disorders still continues to be a major killer of mothers around the globe. Its complex pathophysiology starting with abnormal placentation with endothelial dysfunction, still remains unclear. This study aims to know alteration in serum and urinary calcium levels in cases of Gestational Hypertension and Pre-eclampsia. Primary objective was the evaluation of urinary calcium and creatinine excretion levels and find out calcium-creatinine ratio in patients with Gestational Hypertension and pre-eclampsia and compare it with normal pregnant women.

Method: 54 Gestational hypertensive cases and 54 normal pregnant women were included in the study based on inclusion and exclusion criteria. Urinecalcium and creatinine and serum uric acid, total protein, albumin and serum sodium were estimated in corresponding samples collected from patients. Urinary calcium was estimated by Arsenazo method and creatinine by modified Jaffe’s method.

Result: It was found that urinary calcium was decreased in both pre-eclampsia and gestational hypertensive patients compared with the controls, and a significant decrease is seen in urine CCR. The CCR had a sensitivity and specificity of 90.9% and 76.7% respectively.

Conclusion: Decreased urinary calcium excretion in pre-eclampsia and pregnancy induced hypertensives compared to normal pregnant women found to be significant and urine CCR is significantly decreased in pre-eclampsia patients compared to pregnancy induced hypertensives.

Keywords: GHTN, PET, BMI, Hypocalciurea, CCR.

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