Impact of CD4+ lymphocyte count on left ventricular systolic function in newly diagnosed HAART naïve HIV/AIDS patients seen at University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State

Title: Impact of CD4+ lymphocyte count on left ventricular systolic function in newly diagnosed HAART naïve HIV/AIDS patients seen at University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State

Authors: A.C. Mankwe ND, MBBCH, MSc, FWACP, O. J. Odia MBBS, FMCP, FWACP, FRCP, Edin

DOI: https://dx.doi.org/10.18535/jmscr/v5i3.01

Abstract

Background: HIV-related cardiomyopathy is a notable complication of HIV infection attributed to various aetiologic factors including myocardial infection with HIV itself, opportunistic infections, nutritional deficiencies and cardiotoxicity from therapeutic or illicit drugs. These factors become more manifest as CD₄⁺ count decreases in the clinical course of HIV infection.

Method: This was a cross-sectional case-control study. One hundred newly diagnosed HAART naïve HIV/AIDS subjects and one hundred age and sex matched HIV negative controls were recruited and evaluated clinically. CD₄⁺count of the cases were estimated. Left ventricular function was assessed using transthoracic echocardiography.

Results: Systolic dysfunction assessed using ejection fraction was more common in the cases than in the control group (26% versus 5%). There was statistically significant difference in the systolic function of the two groups (p=0.001) and a significant positive correlation between the ejection fraction and CD₄⁺ count (r=0.310, p=0.002). Subjects with CD₄⁺ count <200 cells/µL were more likely to have systolic dysfunction (OR=3.33, P=0.01).

Conclusion: Left ventricular systolic dysfunction was shown in this study to be more common in people with HIV/AIDS than in the control group and there was a significant positive correlation between CD4⁺ lymphocyte count and left ventricular systolic function.

Recommendation: The heart may be a marker of the HIV infected patient’s overall health, and a decline in cardiac function may suggest low CD₄⁺ count and should trigger more comprehensive evaluation and possibly early intervention of the patient.

Keywords: Systolic function, CD4⁺ count, HIV, ejection fraction, echocardiograghy.

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Abstract

Call For Paper Volume 12 Issue 12 December 2024

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Impact Factor SJIF 2024: 7.892

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