Abstract
Introduction: Stroke is defined as ‘abrupt onset of a neurological deficit that is attributable to a focal vascular cause. The role of circulating lipids and lipoproteins in the pathogenesis of ischemic stroke remains uncertain despite three decades of research.
Aim:1) To evaluate lipid profile 2) To study the association between serum lipids and ischemic stroke Materials and Methods: This study was carried out in Mamata General & Super Specialty Hospital, attached to Mamata Medical College, between September 2013 and August 2015 in 50 patients of>35 years of age.
Results: The youngest patient in the study was 35 years old and the eldest was 83 years old. Maximum number of patients were in age group ≥ 65.60% of the cases were males and 40% of patients were females. There is male preponderance.MCA is involved in 58% cases. Out of 30 males 4, and out of 20 females 7, patients had hyperlipidemia. Hyperlipidemia was 3rd major risk factor (22%) for stroke after hypertension and smoking.
Conclusion: Thus prevention of atherosclerosis rather than treatment is the goal. Drug treatment for hyperlipidemia should be individualized based on the calculated risk and as per latest available guidelines.
KEY WORDS: Ischemic cerebro vascular disease (ICD), Stroke, Hyperlipidemia.
References
1. Harrison's principles of internal medicine, eighteenth edition, page 3270.
2. Strong K, Mathers C, Bonita R. Preventing stroke: saves lives around the world. Lancet Neurol 2007; 6:182-7
3. Eyal Shahar, MD, MPH; Lloyd E. Chambless, PhD; Wayne D. Rosamond, PhD; Lori L. Boland, MPH; Christie M. Ballantyne, MD; Paul G. McGovern, PhD†; A. Richey Sharrett, MD, DrPH . Plasma Lipid Profile and Incident Ischemic StrokeThe Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 2003; 34:623-631.
4. Das S, Banerjee T. Stroke Indian Scenario. Circulation 2008; 118: 2719-24.
5. Bhattacharya S, Prasarsaha S, Basu A, Das K. A 5 year prospective study of incidence, morbidity and mortality stroke profile on stroke in a rural community of Eastern India. J Indian Med Assoc 2005; 103(12): 655-9.
6. Alok Mohankar, Ravindra Kumar Garg et al. Serum Lipids and Stroke. Neurology India 1993; 41 (1): 1-5.
7. Linden Strorn E, Boysen G, Nyboe J et al. Influence of total cholesterol, high density lipoprotein cholesterol and triglycerides on risk of cerebrovascular study. The Copenhagen City Heart Study. BMJ 1994; 309: 11-15.
8. Iso H, Jacobs DR, Wentworth D, Neaton JD, Cohen JD. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. N Engl J Med. 1989;320(14):904–910.
9. Tirschwell DL, Smith NL, Heckbert SR, Lemaitre RN, Longstreth WT Jr, Psaty BM. Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups. Neurology. 2004;63(10): 1868–1875.
10. Vishal B Jani, Saqib S Chaudhry, VikramJadhav, Sayed Hussain, Adnan Safdar, and Adnan I Qureshi, Stroke. 2014; 45:AWP338.
11. Philip Barter, European Heart Journal Supplements (2005) 7 (Supplement F), F4–F8 doi:10.1093/ eurheartj/sui036.
12. Karen L. Furie, Scott E. Kasner, Robert J. Adams, Gregory W. Albers, Ruth L. Bush, Susan C., Stroke. 2010, doi:10.1161/STR.0b013e3181f7d043.
13. Kurth T, Everett BM, Buring JE, Kase CS, Ridker PM, Gaziano JM. Lipid levels and the risk of ischemic stroke in women. Neurology. 2007;68(8):556–562.