The haemolytic effect of aqueous leaf extracts of Carica Papaya, Psidium Guajava and Mangifera Indica was investigated using albino rats. The rats were acclimatized feeding on commercial rats feed and water for a period of 20 days. The rats were than grouped in to four (4) using group 1 as controls. The remaining groups were used as subjects. The subjects were administered 4ml (20mg/kg) of the leaf aqueous extracts of the experimental plants for three (3) days. The blood sample was collected in an EDTA bottles, the blood taken was inverted slightly to ensure the EDTA mixed with blood in order to avoid clotting prior to the analysis. The packed cell volume (PCV) was analyzed using Haematocrit (Micro method). Red Blood Cell Count (RBC) was analyzed using haemocytometer method. The result obtained was expressed inform of Mean±SD student t-test and ANOVA analysis were used to compared between subjects and controls using SPSS version 20. The aqueous leaf extract of Mangifera Indica showed insignificant decrease in PCV value of the treated rats compared to the corresponding controls(P>0.05); Also the aqueous leaf extracts of Psidium Guajava showed insignificant increase jn the PCV value of the treated rats compared to their corresponding controls (P>0.05).Whereas the leaf aqueous extracts of Carica Papaya showed significant decrease in the PCV value of the albino rats treated compared to their corresponding controls (P<0.05).The RBC values obtained in the albino rats treated showed slight decrease compared to their corresponding control but does not register any significant difference (P<0.05). Therefore the leaf aqueous extracts of Carica Papaya which showed significant decrease in the PCV value of the albino rats treated compared to their corresponding controls (P<0.05) was found to have haemolytic effects.

Key Words:  Haemolytic, PCV, RBC, Carica Papaya, Psidium Guajava, Mangifera Indica.