Title: Nephrotic Syndrome: Clinico-Histopathological Spectrum in Tertiary Care Hospital of Rohelkhand of U.P (Bareilly)

Authors: Varshney Amit, Gupta Vijay, Sachan Amit, Singh Rohit, Nigam P


DIDS : 08.2015-83974496


Nephrotic syndrome is a clinical entity characterized by massive proteinuria (primary albuminuria) leading to hypoproteinemia (hypoalbuminemia) leading to edema and fluids in serous cavities of the body. Hyperlipidemia, hypercholesterolemia and lipiduria are usually associated.

The present study was carried out to analyze the clinico-pathological correlation, asses the value of histopathology as well as to note the spectrum of renal disease in patients with significant proteinuria. Eighty four patients having evidences of nephrotic syndrome were included in this study and underwent ultrasound guided percutaneous renal biopsy. Clinical information was correlated with the pathological finding and results were analyzed. Their age ranged from 7 to 78 years (36.5± 16.7 years) with male to female ratio of 1.2:1. The common presentation of nephrotic syndrome was seen in 83 cases (98.8%) edema, with/without general anasarca, anemia (92.8%) , increase in body weight (80.9%) and ascites (73.8%) were common clinical manifestation. Primary glomerular disease (80.9%) were more common than secondary glomerular disease (19.1%). overall, the most common pathological diagnosis was MG/DLN(25%) and FSGS(20.2%) followed by MPGN(13.1%). The disease were more common in 21 to 40 yrs age group (30 cases o 35.7%) followed by 41 to 60 yrs (27 cases or 32.1%).

Our study reinforces the knowledge that renal biopsy helps in accurate diagnosis and thus help in appropriate management of patient. The MG/DLN and FSGS were common cause of nephrotic syndrome in the productive age group.

Keywords: nephrotic syndrome, focal segmental glomerulo sclerosis, membranous nephropathy, minimal change disease, renal biopsy.


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Crossref - DOI Prefix: 10.18535/jmscr


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