Background: Pemphigus is a group of rare, chronic, autoimmune, potentially fatal vesiculobullous diseases of the mucous membranes and skin.  Clinical profile and epidemiologic characteristics varies in different parts of the world. Aim: The aim of this study was to evaluate the clinical and epidemiological features of pemphigus in our hospital and to compare the results with those in the literature.

Methods: All newly registered patients with confirmed pemphigus admitted at the Department of Dermatology between the period August 2009 and July 2015 were evaluated. Demographic variables and clinical presentation, treatments received were recorded.

Results:Out of 91 patients diagnosed aspemphigus in our centre during the period of 6 years pemphigus  vulgaris  was the most common type (91.2 %). The mean age of onset was 45 years.  Male to female ratio in the patients with pemphigus vulgaris was 1: 1.5. Oral lesions were found in 84 % of patients and it was the first manifestation in 66%. Mortality rate was 1% (2 cases) which was due to sepsis. There was no mucosal involvement in patients with pemphigus foliaceus. Only 1 patient had a positive family history. No seasonal predominance for the onset of the disease was noted.

Conclusion: Pemphius vulgaris is the predominant form of pemphigus seen followed by pemphigus foliaceus. Oral mucosa as well as skin are the major sites of involvement. Due to increase in life expentancy occurance of Pemphigis is not  an uncommon condition  in elderly individuals.

Keywords-Pemphigus vulgaris, pemphigus foliaceus, clinico-epidemiology, skin, oral