Association of BER Genes Polymorhism, XRCC3 and XRCC1 with Risk of Gastric Carcinogenesis: A Case Control Study from Eastern India

Title: Association of BER Genes Polymorhism, XRCC3 and XRCC1 with Risk of Gastric Carcinogenesis: A Case Control Study from Eastern India

Authors: Kamalika Roy M.Sc (Med Micro), Prof. Tamal Kanti Ghosh MD, PhD, MBA, Sushil Kumar PhD, Prof UC Ghoshal MD,DM (Gastro), DNB, Dr Sumohan Biswas

DOI: http://dx.doi.org/10.18535/jmscr/v3i8.03

DIDS : 08.2015-51246793

Abstract

References

Corresponding Author

Abstract

The aim of the study was to investigate the association between XRCC3 Thr241Met and XRCC1 Arg194Trp polymorphism and risk of gastric carcinogenesis in eastern Indian population. A total of 508 subjects (168 patients with gastric cancer, 170 with dyspepsia and 170 controls; age and gender matched) were prospectively investigated for this case control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to distinguish XRCC3Thr241Met and XRCC1 Arg194Trp polymorphism and risk of Gastric Carcinoma (GC). Statistical analysis was done by two-sample t-test for continuous variables and χ2test for categorical variables. Logistic regression models were used to find the risk factors for Gastric cancer. Subjects were matched for age and gender in all three groups except GC Vs. HC group. XRCC1 Arg194Trp genotypes were comparable among three group XRCC3Thr241Met Trp/Met has protective role and Met/Met mutant allele does not show any risk of gastric cancer

Key Words: Gatsric Cancer, XRCC1, XRCC3, polymorphism

References

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