Title: Pharmacogenomics of Anesthetic Agents: Tailoring Anesthesia to Individual Patients
Authors: Abdullatif Eid Alghamdi, Shabab Mohammed Alghamdi, Abdulrahman Mahdail Aljubari, Mazen Fawaz al Alharthi
DOI: https://dx.doi.org/10.18535/jmscr/v11i12.10
Abstract
This report explores the transformative impact of pharmacogenomics on the field of anesthesia, focusing on tailoring anesthesia to individual patients. Pharmacogenomics investigates genetic variations influencing responses to anesthetic agents, offering insights into drug metabolism, receptor sensitivity, and overall pharmacokinetics. The integration of genetic data into anesthesia practice enables personalized medicine by optimizing drug selection and dosages based on an individual's genetic profile. Key considerations include the influence of genetic polymorphisms in drug metabolism enzymes, such as cytochrome P450, and the role of genetic variations in drug receptor genes. The report addresses challenges and ethical considerations associated with implementing pharmacogenomics in routine anesthesia practice. Adopting the potential of pharmacogenomics in molding the future of anesthesia care sustains promise for enhancing patient safety and results in the perioperative context.
Keywords: Pharmacogenomics, Individual patients, Anesthetic agents, Drug.
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