Title: Pyometra Associated with Xanthogranulomatous Endometritis (XGE): A Case Report
Authors: Bandana Mehrotra, Ashok Kumar Kapoor, Harshit Bajpai, Supriya Mehrotra, Ruchi Shukla, Hari Shyam, Rajesh Kumar Srivastava
DOI: https://dx.doi.org/10.18535/jmscr/v10i11.07
Abstract
Xanthogranulomatous endometritis (XGE) is a rare disease clinically simulating endometrial carcinoma [1,2]. It is a type of chronic inflammation comprising of lipid-laden macrophages (MØ), lymphocytes and multinucleated foreign body giant cells. Current lesion rarely develops in female genital system. So far 20 cases were reported worldwide[3]. Exact etiopathogenesis of the lesion is unknown. Several different bacteria e.g. Peptostreptococcus magnus, Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris had been isolated earlier from similar lesion[4,5]. Present case presented with extensive collection of pus in uterine cavity. However, in the current case, pus culture was sterile and we could not isolate any microbe from pus.
Keywords: Pyogenic infection, foamy macrophages, chronic inflammation, lymphocytes.
References
- Makkar M, Gill MK, Singh DP. Xanthogranulomatous endometritis: An unusual pathological entity mimicking endometrial carcinoma. Ann Med Health Sciences Res. 2013;3: Supplement.
- Malik A, Dudani S, Mani NS. Xanthogranulomatous endometritis presenting as pyometra and mimicking carcinoma on imaging. J Mid-life Health. 2016;7:88-90.
- Wader JV, Jain A, Kumbhar SS, Vhawal V. Histiocytic endometritis.2013; 14:329-32.
- Noack F, Briese J, Stellmacher F, Hornung D, Horny H. Lethal outcome in xanthogranulomatous endometritis : 2006;114:386-8.
- Barua R, Kirkland JA, Petrucco OM. Xanthogranulomatous endometritis: Case report. Pathology. 1978;10:161- 4.
- Buckley CH, Fox H. Histiocytic endometritis. Histopathology.1980;4:105-10.
- Dogan-Ekici I, Usubutun A, Kusukali T et al, Xanthogranulomatous endometritis: A challenging imitator of endometrial carcinoma. Infect Dis Obstet Gynecol.2007:34763.
- Takenchi K, Yoshida Ai, Sugimoto M, Fujita M, Morita H. Xanthogranulomatous inflammation of myometrium causing pelvic extension : Report of two cases. Open J obs Gynecol 2022,12,147-53.
- Genta RM, Connor DH. Infections and parasite disease in ʽPathologyʼ. Rubin E, Farber JL (ed.) Lippincott – Raven NY (publishers) p 394-95 and p 423.