Nanosuspension is one of the most promising approaches for the enhancement of oral bio-availability of poorly soluble drugs. In this current research work, 13 different formulations of surfactant-stabilized nanosuspension of canagliflozin polymeric nanoparticles were developed and optimized based on average particle size distribution, entrapment efficiency, and zeta potential. In-vitro drug release and kinetics experiments were also investigated. The nanoparticle formulation CGF-12 was found with optimum results in particle size distribution and zeta potential analysis. The %EE of drug in the prepared nanosuspension was in the range of 49.5 ± 0.70 to 100 ± 2. In in-vitro drug release studies, CGF-12 formulation showed maximum drug release of 100% in distilled water within 3 hours, 93% in HCl media at the end of 8 hours and reached 100% in phosphate buffer media within 2 hours. Hence, the formulated canagliflozin polymeric nanoparticles are good choice to improve physicochemical properties of the drug and these formulations improve canagliflozin drug efficacy.

Keywords: Canagliflozin, Nanosuspension, Physicochemical, Drug release and Drug kinetics.

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Anusha Ponnusamy

Research Fellow, Multi-Disciplinary Research Unit, Thanjavur Medical College, Thanjavur (TN)