The siddha medicine is among oldest system of medicine in India. The Civakaranthai ilai cūranam has been mentioned in classical literature Gunapadam Mooligai Vaguppu for the management of cegana vatham and it has been correlated symptoms in modern medicine in cervical spondylosis.

Objective: The objective of this study was to investigate the acute toxicity of siddha herbal formulation

Method: Acute toxicity of civakaranthai ilai cūranam (CKC) is carried out as per the OECD -423 guidelines on the acute toxicity study were used in female albino Wister rats. The test drug CKC was administered single dose at 5 mg/kg,50 mg/kg,300 mg/kg,1000 mg/kg,2000 mg/kg body weight of animal for 14 days administered all group of treated animals.

Results: The results are assessed for detect the effect of  civakaranthai ilai cūramam .In acute toxicity study there is no mortality and behavioural changes are observed in treating the animals in civakaranthai ilai cūranam (2000mg/kg) indicating the p value is less than 0.05.

Conclusion: There were no mortality was observed in civakaranthai ilai cūranam (CKC).So civakaranthai ilai cūranam was safer and can be prescribed for therapeutic use in humans.

Keywords: civakaranthai ilai cūranam, Siddha medicine, Toxicity study.

1. K, Yugi Vaithiya Sinthamani 800 2^nd edition, Pg. no:106.
2. Murugesa Mudaliyar, Gunapadam Mooligai Vaguppu,Edition2008,228.
3. I, Pitchiahkumar. M, Visweswaran.S, Evaluation of Acute toxicity study of Siddha drug Eachuramooli Chooranam, Int. J. Adv. Res. Biol. Sci. (2019).6 (12):126-130.
4. N. Yoganarasimhan medicinal plants of india Volume.2,.1425.
5. M, Manoharan. A, Acute And Chronic Toxicity Study of Siddha Herbal Formulation Nelli Kudineer Samulam, Indian Journal Of Applied Research, Volume -9,Issue-4,April-2019,ISSN No 2249-555X.
6. V.S. Sambasivampillai Tamil and English dictionary.Vol-3,pg.no:2206.

Dr Manoharan A

Professor & HOD, Dept. of Pothu Maruthuvam, Government Siddha Medical College & Hospital, Palayamkottai-627002, Tirunelveli, Tamil Nadu