Background: Stroke is one of the most frequent causes of death and disability worldwide with a big significant clinical and socioeconomic impact. It has a heterogeneous etiology including unmodifiable risk factors like genetic, age, and sex, and modifiable risk factors including hypertension, diabetes mellitus, dyslipidemia, and smoking. In the recent past, studies have indicated that vitamin D deficiency is predictive for future strokes, but the evidence is limited.

Aims and Objective: To determine the role of 25-hydroxyvitamin D levels on the occurrence of ischemic stroke and its comparison with age and sex-matched controls.

Material and Methods: A case-control study was done and a total of 48 patients with acute ischemic stroke were chosen. An equal 48 controls were included in this study for the comparison of outcome. 25-hydroxy vit D levels were measured by chemiluminescence assay using commercially available kits.

Results: Mean Vitamin D Levels among cases and controls were 15.46 ±8.41 and 26.74 ± 13.28, respectively. There is a significant difference observed between the case and control group while comparing mean vitamin D levels, p-value < 0.0001 (highly significant). Vitamin D deficiency (<20 ng/ml) is inversely related to the incidence of ischemic stroke (odds ratio = 4.109 within a 95% confidence interval of 1.74 to 9.71).

Conclusion: We found that vitamin D deficiency is associated with an increased risk of ischaemic stroke.

Keywords: stroke, 25-hydroxy vitamin D,

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Gaurav Gupta