NUT Midline carcinoma (NMC) is a very rare, poorly differentiated malignancy which is highly aggressive. Genetic hallmark is rearrangement in NUT gene located in chromosome 15. The median survival time of NMC patients is only 6.7 months despite of surgical resection or chemoradiotherapy, and most patients with NMC have been diagnosed with locally advanced or metastatic diseases. This is a case of a 36 year old lady with nasal cavity mass which turned out to be NUT Midline carcinoma.

Keywords-NUT gene, NMC, BETi.

1. French CA. Pathogenesis of NUT midline carcinoma. Annu Rev Pathol. 2012; 7:240+67–265. [PubMed: 22017582
2. Bishop JA, Westra WH. NUT midline carcinomas of the sinonasal tract. Am J Surg Pathol. 2012;36:1216–1221. [PubMed: 22534723]
3. Stelow EB, Bellizzi AM, Taneja K, et al. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J SurgPathol. 2008; 32:828–834. [PubMed: 18391746]
4. Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Luer SC, et al. Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res. 2012;18(20):5773–9.
5. Haack H, Johnson LA, Fry CJ, et al. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009;33(7):984-991.
6. Bellizzi AM, Bruzzi C, French CA, et al. The cytologic features of NUT midline carcinoma. Cancer. 2009;117(6):508-515.
7. Nuclear Protein in Testis (NUT) Midline Carcinoma: A Rare Aggressive Solid Tumor
8. Bishop JA, French CA, Ali SZ. Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients. Cancer Cytopathol. 2016;124 (12):901-908.
9. Stelow EB. A review of NUT midline carcinoma. Head Neck Pathol. 2011;5(1):31-35.
10. French CA. The importance of diagnosing NUT midline carcinoma. Head Neck Pathol. 2013;7(1):11-16.

Rejnish Kumar

Division of Radiation Oncology, Regional Cancer Centre, Medical College Campus, Ulloor, Thiruvananthapuram, Kerala, India 695011