Title: A Case Report on Rare Presentation of Thymoma with Extensive Necrosis
Authors: Dr Monica Sarohi, Dr Kavita Mardi
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.34
Abstract
In adults thymoma are the most common primary tumor in the anterior mediastinum but thymoma with extensive necrosis is extremely rare. This presentation of thymoma is challenging for both pathologists and radiologists. Massive areas of necrosis makes it difficult to report and categorize without the immunohistochemical staining. We present a case of a 42 year old female from himachal Pradesh, India presenting with chest pain and pain radiating to right arm which was diagnosed as a thymoma with extensive necrosis.
Keywords: Thymoma, extensive necrosis, anterior mediastinal mass.
References
- Srirajaskanthana R, Toubanakisa C, Dusmetb M, Caplina ME. A review of thymic tumours. Lung Cancer 2008;60:4-13.
- Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest 2005; 128(4):2893-909.
- Moran CA, Suster S. Thymoma with prominent cystic and hemorrhagic changes and areas of necrosis and infarction: a clinicopathologic study of 25 cases. Am J Surg Pathol 2001, 25: 1086-1090.
- Rosai J, Sobin L. Histological typing of tumours of the thymus. In: Rosai J, Sobin L, eds. World Health Organization, international histological classification of tumours. Berlin, New York: Springer, 1999:9-14.
- Müller-Hermelink HK, Ströbel P, Zettl A, et al. Combined thymic epithelial tumours. In: Travis WD, Brambilla E, Müller Hermelink HK, Harris CC, eds. Pathology and genetics of tumours of the lung, pleura, thymus and heart (WHO classification of tumours series). Lyon, France: IARC Press, 2004:196- 8.
- Detterbeck FC. Clinical value of the WHO classification system of thymoma. Ann Thorac Surg 2006;81:2328-34.
- Cui W, Zhang D, Tawfik O: Thymoma with extensive necrosis: a case report and review of literature. Pathologica 2006, 98: 652- 654.
- Hayashi S, Hamanaka Y, Sueda T, Shikata H, Matsuura Y: A case of thymoma showing extensive necrosis. Nippon Kyobu Geka Gakkai Zasshi 1993, 41: 1578-1581.
- Lopez-Cano M, Ponseti-Bosch JM, Espin-Basany E, Sanchez Garcia JL, Armengol-Carrasco M. Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis. Ann Thorac Surg 2003;76(5):1643-9.
- Detterbeck FC, Parsons AM. Thymic tumors. Ann Thorac Surg 2004;77(5): 1860-9.
- Marx A, Ströbel P, Zetti A, Chan JKC, Müller-Hermelink HK, Harris NL, Kuo TT, Shimosato Y, Engel P: Thymomas. In: Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (eds). World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart, Lyon, IARC Press, 2004, 152-156.
- Sumiyama Y, Yoshida Y: Thymoma. Ann Thorac Cardiovasc Surg 2004, 10: 321-323.
- Suster S. Diagnosis of thymoma. J Clin Pathol 2006;59(12):1238- 44.