Background: Pre-eclampsia is an obstetric condition that affects pregnant women and their fetuses. It is a leading cause of maternal and neonatal morbidity and mortality. Platelet activation and destruction is a well- recognized feature of pre-eclampsia, but the current literature is contradictory regarding the role of mean platelet volume (MPV) in the diagnosis of this condition.

Objective: The aim of this study is to evaluate the mean platelet volume (MPV) as a method for diagnosis of preeclampsia by comparison between MPV in normal pregnancy and preeclampsia.

Patients and Methods: The present study was a comparative case control study that was done during the period of research from May 2018 to February 2019 at obstetrics department of Shebin Elkom Teaching hospital, Menoufia University and comprised (100) pregnant women who were divided into two groups: Group 1: 50 pregnant Egyptian women with preeclampsia (cases). Group 2: 50 disease- free pregnant women (control) after the 20^th week of gestation.

Results: In this study, MPV can differentiate normotensive pregnant women from preeclamptic pregnant women at a cut off value 10.05 (fl) with sensitivity of 90 % and specificity of 78 %, PPV of 80.4 %, NPV of 88.6 %. MPV has largest area under the curve (AUC= were 0.896; CI :(0.836-0.957), indicating its importance for predicting preeclampsia.

Conclusion: MPV measurement is useful in predicting preeclampsia if used in combination with other more sensitive tests. If no other test is available, it might be indicative Kenchaials e to a certain degree.

Keywords: Mean Platelet Volume, Pre-eclampsia, Normal Pregnancy.

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Shihab El Dien Mohamed Nazmy Amer