Title: Correlation of serum uric acid with lipid profile in pre-eclamptic patients
Authors: Lata Bishnoi, Nagraj Soni, Anita Verma
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.106
Abstract
Introduction: Pre-eclampsia is one of the largest causes of maternal and fetal mortality and morbidity. Dyslipidemia and hyperuricemia have been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations.
Objective: The aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with uric acid.
Materials and Methods: The present study was conducted on 50 normal pregnant women (Group-I), 50 Pre-eclamptic pregnant women (Group-II). The blood samples collected from all the women and analyzed for serum lipid profile and uric acid.
Results: Mean serum uric acid and triglyceride levels (p<0.001 and p<0.05 respectively) were significantly higher and total cholesterol and LDL-C were increased and HDL-C was decreased but the results were not statistically significant in pre-eclampsia group as compared to normal pregnant group. Positive correlation of uric acid was seen with total cholesterol and HDL-C and negative correlation with triglycerides and LDL-C. But the correlation was not statistically significant.
Conclusion: Measurement of serum lipids and uric acid may be helpful in early diagnosis and prevention of maternal and fetal complications in preeclampsia.
Keywords: Preeclampsia, Normal pregnancy, Dyslipidemia, lipid profile, uric acid.
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