Myeloneuropathy is a frequently encountered condition and often poses a diagnostic challenge¹. Myeloneuropathy arises from a variety of nutritional, toxic, metabolic, infective, inflammatory, and paraneoplastic disorders⁴. Vitamin B12, folic acid, copper, and vitamin E deficiencies may lead to myeloneuropathy resembling as that of subacute combined degeneration of the spinal cord⁶. Chikungunya viral infection has been shown to produce a syndrome similar to myeloneuropathy. Human immunodeficiency virus (HIV) infection may resemble subacute combined degeneration⁹. Magnetic resonance imaging (MRI) in subacute combined degeneration of the spinal cord typically reveals characteristic signal changes on T2-weighted images of the cervical spinal cord. Once myeloneuropathy diagnosis is suspected, all these patients should be subjected to a battery of tests¹¹.  Vitamin B12, folic acid, vitamins A, D, E, and K serum levels along with levels of iron, methylmalonic acid, homocysteine, and calcium should be assessed¹³. Clinical features resembling myeloneuropathy along with the battery of biochemical tests often helps in establishing the correct diagnosis.

Keywords: Myeloneuropathy, Posterolateral syndrome, Demyelination.

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Dr S.Vignesh

Post-Graduate, Dept. of Medicine, Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Puducherry 605107, India