Von Recklinghausen disease, also known as neurofibromatosis 1 is one of the commonest neurocutaneous disorders. It is associated with an increased risk of developing benign and malignant tumors. However, only few case reports are mentioned in literature associating neurofibromatosis with autoimmune disorders, vitiligo being one of them. We report a case of 30 years old female, who presented with cutaneous features of neurofibromatosis 1 and vitiligo. Interestingly, she had multiple neurofibromas, which were characteristically depigmented. Only few case reports have been mentioned in literature associating these two disorders. Whether this exists due to some underlying genetic defect of NF1 gene or mere coincidence, it is yet to be found.

Keywords: neurofibromatosis, vitiligo, coincidence.

1. Nanda A. Autoimmune diseases associated with neurofibromatosis type 1.Pediatric Dermatology. 2008; 25(3):392-3.
2. Zampetti M, Flippetti R. Type 1 neurofibromatosis and the vitiligo. G Ital Dermatol Venereol. 2008; 143(5): 352.
3. Nabi J. Neurofibromatosis type 1 associated with Hashimoyo’s thyroiditis: Coincidence or possible link. Case Reports in Neurological Medicine.2013. http://dx.doi.org/10.1155/2013/910656

4. Khaitan BK, Kathuria S, Ramam M. A descriptive study to characterize segmental vitiligo. Indian J Dermatol Venereol Leprol 2012;78:715-21.
5. Bukhari I, Mulhim FA. Neurofibromatosis Type 1 associated with vitiligo and left occipital bone defect. The Internet Journal of Dermatology. 2006; 6(1): 1-4.
6. Singh KK, Kumar A, Mohan L, Mukhija RD, S. Neurofibromatosis in association with vitiligo. Indian J Dermatol Venereol Leprol. 1992; 58:55.

Saru Thakur

Deptt. of Dermatology, Leprosy and Venereology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India