Title: A study of Major Depressive Disorder in Patients with Seizure Disorder
Authors: Dhiraj N. Bhivgade, Nidhi Nagori, Bharat N. Panchal
DOI: https://dx.doi.org/10.18535/jmscr/v7i4.158
Abstract
Background: Epilepsy is chronic neurological disorder that have profound physical, social and psychological consequence. The prevalence of depression is much more in patients with seizure disorder. We studied the frequency of major depressive disorder in patient with seizure disorder.
Methods: This was a single-centered, cross sectional, observational, questionnaire based study. Hundred patients who attended psychiatry outpatient department of tertiary care hospital with history of seizure disorder at-least for one year duration were included in the study, diagnosis of major depressive disorder was done by clinician administered interview as per DSM-V. The patients assessed for demographic details, NHSSS (National Hospital Seizure Severity Scale) and HAM-D (Hamilton rating scale for depression).Data were analyzed by Graph Pad In Stat version 3.06
Results: Frequency of major depressive disorder in patient with seizure disorder is 33%. The patient with major depressive disorder showed higher score on HAM-D (p< 0.0001).
Conclusion: Patient with seizure disorders are prone to Major Depressive Disorder with higher HAM-D score.
Keywords: Depression, Seizure Disorder, HAM-D, Seizure Severity
References
- Allison Clarke, The impact of epilepsy on well being of young people, The Epilepsy report Issue 1 , May 2008.
- Jacoby A, Snape D, Baker GA. Determinants of quality of life in people with epilepsy. Neurol Clin 2009;27:843-63.
- Cramer JA, Blum D, Reed M, Fanning K. The influence of comorbid depression on seizure severity. Epilepsia 2003;44:1578–84.
- Goldberg D and Shorvon S(1993) Epileptic seizure in population of 6,000, Demography, diagnosis and classification and role of hospital service Br Med J 287:641-644.
- Shridharan R, Murthy BN ,Prevalence and pattern of Epilepsy in India, Epilepsia 1999, May;40(5):631-6
- M J Jackson, D Turkington, Depression and Anxiety in Epilepsy,J Neurol Neurosurg Psychiatry 2005;76(Suppl I):i45–i47.
- Ahmed Abu Sheer, Thesis study Depression among Epileptic Patients in Governmental Community Mental Health Centers in Gaza Strip, 2009-3472 ;18.
- Rajesh Jacob,*M. Suresh Kumar, R. Rajkumar, and V. Palaniappun ,A study to assess depression ,its correlates and suicidal behavior in epilepsy; Indian J Psychiatry. 2002 Apr-Jun; 44(2): 161–164.
- Djibuti M, Shakarishvili R. Influence of clinical, demographic and socioeconomic variables on quality of life in patients with epilepsy: findings from Georgian study. J Neurology Neurosurgery Psychiatry 2003;74:570-3.
- Berto P. Quality of the life in patients with epilepsy and impact of treatment. Pharmacoeconomics 2002;20:1039-59.
- Andres M Kanner, Depression and anxiety in epilepsy J Neurol Neurosurg Psychiatry 2013 84: e1.
- Fiest, KM, Dykeman, J, Patten, SB, Wiebe, S, Kaplan, GG, Maxwell, CJ, Bulloch, AGM, & Jette, N. Depression in Epilepsy: A Systematic Review and Meta-Analysis. Neurology. 2013; 80(6): 590-599.
- Andres M. Kanner, John J. Barry, Frank Gilliam, Bruce Hermann and Kimford J. Meador, Depressive and anxiety disorders in epilepsy: Do they differ in their potential to worsen common antiepileptic drug–related adverse events;Epilepsia Volume 53, Issue 6, pages 1104–1108, June 2012.
- Develis RF, Devellis BM .et al, Epilepsy and Learned Helplessness ,Basic and applied social psychology ,1980,1:241-53
- Jose F. Tellez-Zenteno, Scott B. Patten, Nathalie Jetté, Jeanne Williams andSamuel Wiebe ; Psychiatric Comorbidity in Epilepsy: A Population-Based Analysis , Epilepsia Volume 48, Issue 12, pages 2336–2344, December 2007.