Title: Cytopathological Analysis of Body Fluids in Conventional Smear Method versus Cell Block Method for Diagnostic Evaluation
Authors: Dr Ashok Yadav, Dr Amrita Tripathi, Dr Priyanka Solanki, Dr Upma Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.191
Abstract
Introduction: The cytological analysis of serous effusions helps in diagnostic, therapeutic and prognostic implications. The accurate identification of cells as either malignant or reactive mesothelial cells is a diagnostic problem in conventional cytological smears. The cell block (CB) technique is one of the oldest and complementary methods for the evaluation of body cavity fluids.
Methods: The present study was conducted on 130 patients who subjected for the diagnosis of body fluid effusion cytology by CS & CB method. A total 130 fluid specimen were received in the Cytology section, Department of Pathology, M.G.M. Medical College, Indore, (M.P.) from DEC 2015 to DEC 2017. All the 130 body fluid specimens were included in the study.
Results: In our study a total of 130 body cavity fluid samples were studied. Out of 130 samples, 63 samples were peritoneal fluid, 60 were pleural, 4 were synovial and 3 were pericardial. All the14.6% cases which were malignant on CS remained so on CB. On CB 23.07 % cases were positive for malignancy, 1.5 % suspicious and rest benign & inflammatory. CB increased the yield of malignancy by approx 8.46% (11 cases). Out of these 11 cases, 9 were suspicious on CS and 2 were benign but turned out to be malignant on CB.
Conclusion: In developing countries like India, where health facilities are inadequate, and cost of investigations and management is often unaffordable, fluid analysis and cytology should continue to be the first line of investigation to screen out the benign and malignant effusion cases. A combined use of smears and cell block is recommended to increased further diagnostic accuracy.
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