Title: Synchronous Primary Endometrioid Type Endometrial & Ovarian Adenocarcinoma; A Rare Case Report
Authors: Yumkhaibam Sobita Devi, Srigopal Mohanty, Laishram Jaichand Singh, C. Lalrindiki, Asit Kumar Jena
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.161
Abstract
Synchronous primary endometrial and ovarian cancer (SEOC) is a relatively uncommon disease. It can be of similar or dissimilar histologies, is commonly diagnosed at younger age, early stage, low grade and have better prognosis as compared to primary endometrial or ovarian cancer alone with metastasis to the other. SEOC presents as a diagnostic challenge for clinicians, as it has both therapeutic and prognostic importance. Here presenting a case of 51 year postmenopausal women presented with bleeding per vagina and pain abdomen for 4 months, which was diagnosed as SEOC of endometrioid subtype, in early stage (both in T1a, low grade, negative margin, no lymphovascular emboli). Considering the early stage and low grade of tumour, she was kept under follow up without any adjuvant therapy and presently has completed 2 years of disease free survival. So while dealing with endometrial malignancies in younger women, a thorough preoperative and intraoperative evaluation needed to rule out SEOC. Accurate diagnosis of SEOC can spare this group of patients from aggressive adjuvant chemotherapy or radiotherapy. Further prospective clinical studies required to establish standard management protocol for SEOC.
Keywords: Endometrioid, Endometrium, Ovary, Synchronous primary carcinoma.
References
- Zaino R, Whitney C, Brady M, Degeest K, Burger R, Buller R. Simultaneously detected endometrial and ovarian carcinomas- a prospective clinicopat-hologic study of 74 cases ; a Gynecologic Oncology group Study. Gynecol Oncol 2001; 83: 355-62.
- Scully R, Young R, Clement P. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. Washington Armed Forces Institute of Pathology. Atlas of Tumor Pathology 1998; 23: (Table 5-1–5-3).
- Walsh C, Holschneider C, Hoang Y, Tieu K, Karlan B and Cass I: Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol 2005; 106: 693-9.
- Chiang YC, Chen CA, Huang CY, Hsieh CY, Cheng WF. Synchronous primary cancers of the endometrium and ovary. Int J Gynecol Cancer 2008; 18: 159–164.
- Oranratanaphan S, Manchana T, Sirisabya N. Clinicopathologic variables and survival comparison of patients with synchronous endometrial and ovarian cancers versus primary endometrial cancer with ovarian metastasis. Asian Pacific J Cancer Prev 2008; 9: 403-40
- Soliman PT, Solmovitz BM, Broaddus RR et al. Sychronous primary cancers of endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol 2004; 94: 456-62.
- Nicholson MR, Iyengar P, Hummer AJ, Linkov I, Asher M, Soslow RA. Immunophenotypic diversity of endometrial adenocarcinomas: implications for differential diagnosis. Mod Pathol 2006; 19: 1091-1100.
- Lax SF: Pathology of endometrial carcinoma. Adv Exp Med Biol 2017; 943: 75-96.
- Goyal A, Masand RP and Roma AA. Value of PAX-8 and SF-1 immunohist-ochemistry in the distinction between female adnexal tumor of probable wolffian origin and its mimics. Int J Gynecol Pathol 2016; 35: 167-75.