Title: A study of Infection-related glomerulonephritis (IRGN) from a tier-2 city in Southern Tamilnadu
Author: Dr S. Balamurugan. M.D.,D.M
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.86
Abstract
Infection-related glomerulonephritis (IRGN)/Postinfectious glomerulonephritis (PIGN) is an immune-mediated glomerulonephritis caused by non-renal bacterial viral infections. In children it usually follows skin or pharyngeal infection followed by acute Nephritic syndrome. However in adults IRGN presentation more often in an atypical way. This study was done in a retrospective manner wherein we had analysed the way of presentation of those cases whose kidney biopsy was suggestive of IRGN. RPGN, Acute Nephritic syndrome or Nephrotic syndrome with or without renal failure or Renal failure with Subnephrotic proteinuria are the various presentations we have seen in our study popuation. Many of them had diabetes, Preexisting kidney disease. Most of them had renal failure on presentation. Nearly half of them needed dialysis in the short term. A significant percentage had progresssion to CKD over a period of time. IRGN in adults is not as benign a disease as in children
Keywords: Infection-related glomerulonephritis (IRGN), Post infectious glomerulonephritis (PIGN), RPGN (Rapidly Progressive glomerulonephritis), Acute Nephritic syndrome, Kidney biopsy.
References
- Nasr SH, Fidler ME, Valeri AM et al. Post infectious glomerulonephritis in the elderly. J Am SocNephrol 2011; 22: 17–195.
- Bacterial infection–related glomerulo-nephritis in adults Samih H. Nasr1, Jai Radhakrishnan2 and Vivette D. D’Agati Kidney international(2013) 83, 792–803;
- Ilyas M, Tolaymat A. Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study. PediatrNephrol 2008; 3: 1101–1106.
- Thongboonkerd V, Luengpailin J, Cao J et al. Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors. J Biol Chem 2002; 277:
- Montseny JJ, Meyrier A, Kleinknecht D et al. The current spectrum of infectious glomerulonephritis. Experience with 76 patients and review of the literature. Medicine (Baltimore) 1995; 74: 63–73.6.
- Moroni G, Pozzi C, Quaglini S et al. Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. Nephrol Dial Transplant 2002; 17: 1204–1211.
- Lien JW, Mathew TH, Meadows R. Acute post-streptococcal glomerulonephritis in adults: a long-term study. Q J Med 1979; 48: 99–111.
- Vendemia F, Gesualdo L, Schena FP et al. Epidemiology of primary glomerulone-phritis in the elderly. Report from the Italian Registry of Renal Biopsy. J Nephrol 2001; 14: 340–352.9.