Introduction: Carcinoma of breast is most frequent cancer in India followed by cervical cancer among females as reported in registries from Mumbai, Delhi, Kolkata and Bangalore. Breast cancer is the most common malignancy among women in the world. According to the NCRP (National Cancer Registry Program), around 25% of the total cancer cases are reported to be that of breast cancer. Several anthropological studies have found sex differences in 2D:4D ratio, with man having lower average 2D:4D ratio than women.

Aim and Objective: The aims of this study is to investigate 2D:4D ratio in the diagnosis of breast cancer females and control groups.

Material and Methods: The study was conducted on 145 histopathological diagnosed breast cancer women and their finger length ratio, compared with 145 normal healthy women with no family history of breast cancer. Digit length was measured by the Vernier caliper with a resolution of 0.01 mm.

Results: The finger length 2D:4D ratio were analyzed between breast cancer and control group of individuals that showed statistically difference. In present study 2D:4D ratio (P value<1) is significantly higher in case group as compared to the control group.(table-3). High 2D:4D ratio of significantly associated with breast cancer.

Conclusion: The finger length (2D:4D) ratio may help in identifying women with risk of breast cancer. It can serve as an inexpensive, noninvasive anatomical and effective tool to determine the individuals with breast cancer in their future.

Keywords: Digits ratio 2D:4D, Breast cancer, prenatal sexual Hormone.

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Dr Sajjad Jafar

Assistant Professor, Dept of Anatomy, BRD Medical College, Gorakhpur