Title: Emergence of Drug resistance of salmonella Species, in and around Patna
Authors: Dr Raj Narayan Seth, Dr Satyendu Sagar
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.59
Abstract
Objective: The aim of the present study was to determine the incidence of salmonella species and their emerging trends of drug resistance.
Materials and Methods: A total of 96 patients of different age groups and different sex were presenting with complains of high grade fever from 4 to 6 days of duration, severe headache and abdominal pain in medical OPD, were included in the study. After detailed history specially drug history and clinical examination, they were provisionally diagnosed as a typhoid fever. All the suspected typhoid fever patient’s were send to the laboratory for blood culture. Samples were collected in fully aseptic manner. Isolation, Identification and Drug sensitivity pattern of the causative organism were performed according to CLSI guidelines.
Results: Out of 96 patients, 52 (54.17%) patients were comes in 5-20 years of age, which was the commonest and with male preponderance (61.54%). Female to male ratio was 1:1.52. In the present study a total of 72 (75%) isolates obtained from blood culture, they were highly sensitive to chloramphenical (86.12%), Ampicillin (86.11%), and cotrimoxazole (86%). Highest sensitivity was seen for cephalosporins, followed by Quinolones, 6.95% of the strains to be sensitive to all the drugs and 15.28% were multidrug resistance(MDR).
Conclusion: Study indicates reemergence of chloramphenicol susceptible salmonella species.
Keywords: Salmonella, Drug resistance, Typhoid fever, Reemergence, Susceptible.
References
- David A Pegues, Michael E Ohl, Samuel I Miller: Salmonella species Including Salmonella Typhi Chapter 220: In: Mandell GL, Bennett JE and Dolin R, editors. Principles and Practice of Infectious Diseases. Vol 1. 6 th ed. Churchill Livingstone; 2004. p. 2636-54.
- Jesudason MV, John TJ. Plasmid mediated multidrug resistance in Salmonella Typhi. Indian J Med Res 1992;95:66-7.
- Butt T, Ahmad RN, Mahmood A, Zaidi S. Ciprofloxacin treatment failure in typhoid fever case, Pakistan. Emerg Infect Dis 2003;9:1621-2.
- Saha MR, Dutta P, Niyogi SK, Dutta S, Mitra U, Ramamurthy T, et al. Decreasing trend in the occurrence of Salmonella enterica serotype Typhi amongst hospitalized children in Kolkata, India during 1990-2000. Indian J Med Res 2002; 115:46-8.
- Chande C, Shrikhande S, Kapale S, Agrawal S, Fule RP. Change in antimicrobial resistance pattern of Salmonella Typhi in Central India. Indian J Med
- Sen B, Dutta S, Sur D, Manna B, Deb AK, Bhattacharya SK, et al. Phage typing, biotyping and antimicrobial resistance profile of Salmonella enterica serotype Typhi from Kolkata. Indian J Med Res 2007; 125:685-8.
- Colle JG, Miles RS, Wah B. Tests for the identification of bacteria. In: Collee JG, Fraser AG, Marmion BP, Simmons A, editors, Mackie and Mc Cartney Practical Medical Micrcobiology. London: Churchill Livingstone;
- Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 15 th informational supplements. CLSI document M100-S15. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2005.
- Dutta S, Sur D, Manna B, Bhattacharya SK, Deen JL, Clemens JD. Rollback of Salmonella enterica serotype Typhi resistance to chloramphenicol and other antimicrobials in Kolkata, India. Antimicrob Agents Chemother 2005; 49:1662-3.
- Ray P, Sharma J, Marak RS, Garg RK. Predictive efficacy of nalidixic acid resistance as a marker of fluoroquinolone resistance in Salmonella enterica var Typhi. Indian J Med Res 2006; 124:105-8.