Lymphomas are rarely detected in breast tissue. This study reports a case of Diffuse Large B Cell Lymphoma in the breast with axillary lymph node involvement. The diagnosis was made by excision biopsy and confirmed by immunohistochemistry. Lymphomas can be a rare cause of breast lump in females of any age. Diffuse Large B cell Lymphoma is the commonest subtype among the Non Hodgkin Lymphomas affecting breast. It is difficult to differentiate a case of breast lymphoma from carcinoma by clinical examination and imaging. Tissue diagnosis is essential in evaluating breast lumps for lymphoid neoplasms so that treatment may be promptly initiated.

Keywords: Lymphoma breast, Extra nodal Lymphoma, Diffuse Large B cell Lymphoma.

1. Jennings WC, Baker RS, Murray SS, Howard CA, Parker DE, Peabody LF, et al. Primary breast lymphoma: The role of mastectomy and the importance of lymph node status. Ann Surg. 2007;245(5):784–9.
2. Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer. 1972;29:1705–1712.
3. Joks M, Myśliwiec K, Lewandowski K. Primary breast lymphoma - a review of the literature and report of three cases. Arch Med Sci. 2011;7(1):27–33.
4. Whitfill CH, Feig SA, Webner D. Breast imaging case of the day. Secondary non-Hodgkin (low-grade B-cell follicular small cleaved cell type) lymphoma of the breast.  Radiographics. 1998;18:1038–42.
5. Yang H. Primary Breast Lymphoma ( PBL ): A Literature Review. Clin Oncol Cancer Res 2011(8);128–32.
6. Shim E, Song SE, Seo BK, Kim YS, Son GS. Lymphoma affecting the breast: A pictorial review of multimodal imaging findings. J Breast Cancer. 2013;16(3):254–65.
7. Patne SCU, Kumar M,Khanna R. Cytodiagnosis of Primary Breast Lymphoma in a Young Woman. J Cytol. 2013 Oct-Dec; 30(4): 284–286.
8. Jain MF, Khandekar SL, Mahadani JW, RautWK.Report of a case of primary breast lymphoma high lighting the importance of fine needle aspiration cytology as an initial diagnostic tool.J Cytol. 2015 Apr-Jun; 32(2): 127–129
9. Vannata B, Zucca E. Primary extranodal B-cell lymphoma: current concepts and treatment strategies. Chin ClinOncol 2015:4(1):10.
10. Gupta V, Bhutani N, Singh S, Chhabra S, Sen R. Human Pathology : Case Reports Primary non-Hodgkins lymphoma of breast – A rare cause of breast lump. Hum Pathol Case Reports. 2017;7:47–50.

Annu Elizabeth Prakash

Assistant Professor, Pathology, Sree Narayana Institute of Medical Sciences

Residence Address- Kaliyadan House, Cheriyapilly, Kaitharam P.O., North Paravur, Ernakulam, Kerala 683519, India

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