Title: Adverse Reactions Associated with Single Donor Plateletpheresis Procedures in tertiary care centre at M.Y. Hospital, Indore
Authors: Dr Amrita Tripathi, Dr Ashok Yadav, Dr Priyanka Solanki
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.218
Abstract
Background: Plateletpheresis is a procedure where the whole blood is processed from a donor and the platelets are separated and the remaining blood components are returned back to the donor. Adverse reactions of variable severity may occur during or after the procedure. Adverse reactions that occur in donors can be divided into local reactions and systemic reactions.
Methods: In this study 65 healthy voluntary donors were enrolled after taking the informed written consent and adverse donor reactions of plateletpheresis were noted.
Results: It was observed that out of 65 donors, only three donors had adverse reactions during plateletphersis. Citrate toxicity was seen in one donor (1.6%) ,one donor (1.6%) had bruising on the arm at venipuncture site and another one donor had vasovagal reactions (1.6%) occur mainly in the form of sweating.
Conclusion: Plateletpheresis is one of the well tolerated procedure in which adverse reactions were managed conservatively and rarely need hospitalization.
Keywords: Adverse reactions, Plateletpheresis, Citrate toxicity, vasovagal reactions.
References
- Heuft HG, Moog R, Fi scher EG, Zingsem J. German and Austrian Plateletpheresis Study Group. Donor safety in triple plateletpheresis results from the German and Austrian Plateletpheresis Study Group multicenter trial. Transfusion 2013;53:211-20.
- Hagberg IA, Akkok CA, Lyberg T, Kragh JK. Comparison of three types of cell in apheresis induced platelet activation separators 2000;40:182-92
- Patel AP, Kaur A, Patel V, Patel N, Shah D, Kanvinde S. Comparative study of platelet pheresis using Baxter CS 3000 plus and Haemonetics MCS 3P. J Clin Apher 2004;19:137-41.
- Wallace EL, Churchill WH, Surgenor DM, Cho GS, McGurk S. Collection and transfusion of blood and blood components in the United States 1994. Transfusion 1998; 38:625-36.
- Mcleod BC, Price TH, Owen H, Ciavarella D, Sniecinski I, Randels MJ, et al. Frequency of immediate adverse effects associated with apheresis donation. Transfusion. 1998;38:938–43. [PubMed: 9767744]
- Winters JL. Complications of donor apheresis. J Clin Apher. 2006;21:132–41. [PubMed: 15880355]
- Brecher ME, Leger RM. AABB technical manual. 15th ed. Bethesda: American Association of Blood Banks; 2005.
- Simon TL, Dzik WH. Rossi's principles of transfusion medicine. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2009.
- Crookes RL, Hillyer CD. Blood banking & transfusion medicine. 2nd ed. Philadelphia: Churchill Livingstone; 2009.
- Kanchan Dogra, Parag Fulzele, Diptiranjan Rout, Rahul Chaurasia, Poonam Coshic, Kabita Chatterjee Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital. Indian Journal of Hematology & Blood Transfusion 2017;33 (1): 106-108
- Joseph Philip, Ravi S. Sarkar, and Amardeep Pathak Adverse events associated with apheresis procedures: Incidence and relative frequency. Asian J Transfus Sci. 2013; 7(1): 37–41.
- Kajal Khajuria, Vijay Sawhney , Raman Sharma, Sonia Gup Adverse donor reaction during and after plateletpheresis in a tertiary care centre Int J Res Med Sci. 2017;5(4):1221-1223
- Garg P, Bassi R, Bharadwaj K, Bodal VK. Study of Adverse Donor Reaction of Plateletpheresis in a Tertiary Care Centre of North India. Ann. Int. Med. Den. Res. 2018; 4(2): PT46-PT47.