Introduction: We try to study the best method in diagnosis & therapeutic follow up post treatment respond in osteoporotic patients. Used the advantages of Dexa scan Absorptiometry and bone biomarkers for diagnosis & therapeutics post treatment follow up monitoring of osteoporotic patients were treated by different modalities.

Methods: Prospective comparative studies were randomized according to national osteoporotic foundation. Performed on 200 osteoporotic patients from March 2010 to April 2012, in private clinic sharing private Hematological and Dexa Scan Absorptiometry clinic in Sulaimaniyah city. All these patients with clinical sign of osteoporosis, also all of patients with history of osteoporotic fractures plus surgical history "Hysterectomy, Mastectomy, ooperectomy" were classified into two groups. Group A 100 patients used Dexa scan Absorptiometry for diagnosis & therapeutics treatment monitoring follow up. Group B100 patients were used bone biomarker "Vit D3, PTH, ALK, Osteocalcin" for evaluation & monitoring bone turnover used in diagnosis & therapeutic post treatment follow up of osteoporotic patients. The patients were follow up for 2 years period. The outcome measurements were according to Ancillary results scores of national osteoporotic foundations.

Results: In both group A & group B significant reduction in the mean of Ancillary results scores base line for both Dexa scan Absorptiometry & bone biomarkers were seen early & at 6 months ,1 year and 2 years follow up period visit of osteoporotic patients. Also, there were significant differences (p-value < 0.0001) to the same period of follow up between groups A there were used Dexa scan Absorptiometry as superior to bone biomarkers in diagnosis of osteoporotic patients. In Compared to group B depend on bone biomarkers there were superior in therapeutics post treatment follow up than Dexa scan Absorptiometry.

Conclusions: We concluded that Dexa scan Absorptiometry & Bone Biomarkers both are significant in diagnosis and post therapeutic treatment follow up of osteoporotic patients, However, Bone Biomarkersis superior in post therapeutic treatment than Dexa Scan Absorptiometry which is superior in diagnosis of osteoporotic patients for 2 years study follow up.

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Ahmed Alkhuzai FICMS

Faculty of Medicine, Sulaimani University, Iraq