Objective: A prospective study to compare the outcome of Intralesional triamcinolone alone and intralesional triamcinolone with 5 fluro-uracil combination in cases of hypertrophic scar and keloid.  

Material and Methods: The present study was carried in Department of general surgery S.S. Medical College and Associated S.G.M. Hospital, Rewa (M.P.) Total 66 study patients were included in present study. The studied patients were selected from Surgical O.P.D and I.PD during the period from June 2016 to May 2017.

Depending upon the size, site, duration of lesion, age and sex of the patient, the lesion were treated by intralesional triamcinolone alone and intralesional and 5 fluro-uracil combination in cases of hypertrophic scar and keloids”. Patients will be categorized into 2 groups:

Group A:  Patients with hypertrophic scar and keloid treated with intralesional triamcinolone.

Group B: Patients with hypertrophic scar and keloid treated with intralesional triamcinolone+ 5-fluorouracil.

Evaluation of results for all the 66 patients will be done on the basis of visual inspection and by comparing serial photography.

Results: The 66 subjects in the study were divided into two equal groups of 33(50%) each. Good to excellent results were seen in 18(54.54%) cases in Group A compared to 27(81.81%) in Group B.

Conclusion: A combination regime of intralesional triamcinolone with 5-fluorouracil, found that the combination regime has better results than intralesional triamcinolone alone , in treatment of keloids and hypertrophic scars.

Keywords: 5-Fluorouracil, Hypertrophic scar, Keloid.

1. Davidson S, et al. A primary care perspective on keloids. Medscape J Med. 2009;11(1):18. [PMC free article] [PubMed]
2. Bijlard E, Steltenpool S, Niessen FB. Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol. 2015;95(7):778–782.[PubMed]
3. Wang XQ, et al. A review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids. Ann Plast Surg. 2009;63(6):688–692. doi: 10.1097/SAP.0b013e3181978753.[PubMed] [Cross Ref]
4. Berman B, et al. Prevention and management of hypertrophic scars and keloids after burns in children. J Craniofac Surg. 2008;19(4):989–1006. doi: 10.1097/SCS.0b013e318175f3a7.[PubMed] [Cross Ref]
5. Reish RG, Eriksson E. Scar treatments: preclinical and clinical studies. J Am Coll Surg. 2008;206(4):719–730. doi: 10.1016/j.jamcollsurg.2007.11.022.[PubMed] [Cross Ref]
6. Arno AI, et al. Up-to-date approach to manage keloids and hypertrophic scars: a useful guide. Burns. 2014;40(7):1255–1266. doi: 10.1016/j.burns.2014.02.011. [PMC free article] [PubMed] [Cross Ref]
7. Bouzari N, Davis SC, Nouri K. Laser treatment of keloids and hypertrophic scars. Int J Dermatol. 2007;46(1):80–88. doi: 10.1111/j.1365-4632.2007.03104.x.[PubMed] [Cross Ref]
8. Ledon JA, et al. Intralesional treatment for keloids and hypertrophic scars: a review. Dermatol Surg. 2013;39(12):1745–1757. doi: 10.1111/dsu.12346. [PubMed][Cross Ref]
9. Sharma S, Bassi R, Gupta A. Treatment of small keloids with intralesional 5-fluorouracil alone vs. intralesional triamcinolone acetonide with 5-fluorouracil. J Pak AssocDermatol. 2012;22:35-40.
10. Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, Stefanaki K, Argyrakos T, Petridis A, et al. Intralesional 5-fluorouracil in the treatment of keloids: An open clinical and histopathologic study. J Am AcadDermatol. 2005;52:474-9.
11. Sadeghinia A, Sadeghinia S. Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. Dermatol Surg 2012; 38: 104–109
12. Sharma S, Bassi R, Gupta A. Treatment of small keloids with intralesional 5-fluorouracil alone vs. intralesional triamcinolone acetonide with 5-fluorouracil. J Pak AssocDermatol. 2012;22:35-40.
13. Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, Stefanaki K, Argyrakos T, Petridis A, et al. Intralesional 5-fluorouracil in the treatment of keloids: An open clinical and histopathologic study. J Am AcadDermatol. 2005;52:474-9.
14. Sadeghinia A, Sadeghinia S. Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. Dermatol Surg 2012; 38: 104–109
15. Brian Berman, Harlan Bieley C. “Keloids”. J Am AcadDermatol1995;33; 117-123
16. Griffith BH. The treatment of keloids with triamcinolone acetonide. Plast Reconstr Surg 1966;38: 202-8
17. Griffith BH, Monroe CW, McKinney P: A follow-up study on the treatment of keloids with triamicinolone acetonide. Plast Reconstr Surg 197
18. Asilian A, Darougheh A, Shariati F. New combination of triamcino­lone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg. 2006;32(7):907–915.
19. Davison SP, Dayan JH, Clemens MW, Sonni S, Wang A, Crane A. Efficacy of Intralesional 5-Fluorouracil and Triamcinolone in the Treatment of Keloids. Aesthetic Surg J. 2009;29:40–6.

Dr Shambhu Barua

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