Abstract
Introduction: Burn is injury of flesh that represents one of the most severe forms of trauma caused by heat, electricity, chemicals, light and radiation. Most burns affect only the skin, rarely deeper tissues, such as muscles, bone and blood vessels. A severe burn represents a devastating injury affecting nearly every body organ system and leads to significant patient morbidity and mortality.
Aims and Objectives: The current study on liver enzymes serum aspartate aminotransferase, alanine transaminase , alkaline phosphatase in burn patients was under taken to access and correlate the liver enzymes to the degree of burn injury
Materials and Methods: The study involved 60 hospitalized patients with burn injury irrespective of sex and age between 20-50 years admitted at Gauhati Medical College & hospital between July 2014 to August 2015. Estimation of AST, ALT, ALKP was done in Vitros 5600 by the slide method.
Results and Observations: In the present study ,we found that the liver enzymes, AST,ALT,ALKP were significantly elevated between 5-10 days in the study group as compared with control group(<0.05). Significant variation in the rise of liver enzymes is also seen with different degrees of burn.
Discussion: There is strong association and positive correlation between liver enzymes and degree of burns. The cause of increase rise of liver enzymes AST,ALT,ALKP is due to liver cell damage. Restoration of liver function will improve morbidity and mortality of severely burned patients.
Keywords: Burn, Liver enzymes, AST,ALT,ALKP.
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Corresponding Author
Dr Malavika Barman
Assistant Professor, Department of Biochemistry,
Gauhati Medical College & Hospital, Guwahati
DOI: https://dx.doi.org/10.18535/jmscr/v5i12.92
