Title: Carcinosarcoma of Gallbladder with Metastases in Liver and a Lymph Node
Authors: AK Kapoor, Akanksha Singh, Pratibha Singh
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.184
Abstract
Carcinosarcomas are highly malignant neoplasms where pleomorphic epithelial cells comingle with areas showing mesenchymal differentiation. Herewith, we describe the clinicopathological features of a case of carcinosarcoma gallbladder (CSGB). The patient was a female, aged 60 years. Immunohistochemical (IHC) examination revealed strong positivity of adenocarcinomatous tissue for cytokeratin while sarcomatous tissue showed vimentin antigen positivity. Findings of current case suggested differentiation of pluripotent tumor cells both as epithelial and mesenchymal components. She was diagnosed as a case of CSGB metastasizing in liver and a regional lymph node.
Keywords: Epithelial mesenchymal differentiation in a malignant neoplasm.
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