Title: Assessment of incidence and severity of adverse drug reactions in multidrug resistant tuberculosis patients
Authors: G.Akhil, T.Hussain Naik, Dr P.Manjula, G. Nikhitha
281 patients who were diagnosed as MDR-TB by Department of Chest disease and Tuberculosis hospital, Hanamkonda were enrolled in the study over a period of January 2016 to may 2018. Detection and monitoring of ADR was done by interviewing patient and reviewing laboratory tests on monthly basis till their ATT continued. Patients were instructed to report any sign and symptoms they come across during the treatment period. A total of 317 ADRs were detected, documented, assessed and reported during the study period. The causality assessment of ADRs reveled that most of the ADRs were “possible” in nature. Assessment of severity of the suspected ADRs revealed that 35.78% of suspected ADRs were mild and 51.38% of ADRs were moderate in severity. Early detection, management and reporting of ADRs remain key factors in the management of MDR-TB with remarkable relevance to prevent emergence threat of global MDR-TB.
Keywords: Multi drug resistant tuberculosis, adverse dug reaction, anti tubercular therapy.