Title: Serum vitamin D profile in children with severe pneumonia: A prospective study in a rural institute
Authors: Loganathan Palanivel, Chidambaranathan Sivaprakasam, Logesvar Palanisamy
Background: Vitamin D plays a vital role in the maturation of the skeletal system and immunological functions especially by receptor sensing and signaling. The stable form of vitamin D in the body is 25-hydroxycholecalciferol which is often used as its biomarker.
Methods: The study was done prospectively in the pediatric wards, Rajah Muthiah medical college, and hospital, Chidambaram from October 2016 to June 2018. Out of the 200 children with respiratory compliance, 46 children who fulfilled inclusion and exclusion criteria are included in our study. Using a pre-defined proforma, data were collected and the study population was categorized as children having broncho-pneumonia and lobar pneumonia. SPSS software was used for statistical analyses.
Results: Pneumonia was 1.8 times more common in male children than the female. Majority of children had bronchopneumonia (n=28) followed by lobar pneumonia (n=18) based on clinical examination, laboratory and imaging studies. The mean duration of stay in the hospital is 5.8±.51 days.
Conclusion: Prevalence of vitamin D insufficiency among children with pneumonia is 78.26%.
Keywords: Acute lower respiratory tract infection, 25-hydroxycholecalciferol, pneumonia, bronchiolitis.