Title: Study of Hyponatremia in Cirrhosis of Liver and It’s Prognostic Value
Authors: D.Dinesh Kumar Reddy, C.S.S.Sarma, Madhavi
Objective: Study conducted to know the prevalence of hyponatremia in cirrhosis and to evaluate the association between hyponatremia and complications in cirrhosis and its prognostic value.
Methods: Patients were selected based on clinical examination, biochemical tests and ultrasound abdomen. All the patients were examined at the time of admission in the hospital and their serum sodium levels were checked and the patients were followed during their stay in the hospital. The severity of cirrhosis was assessed according to Child-Pugh score. MELD score and MELD-Na score were also calculated at the time of admission.
Results: Study done on 100 cirrhotic patients, most common etiology for cirrhosis in this study was alcohol. 53% had hyponatremia(<136meq/l). Complications of cirrhosis were more in hyponatremia patients. Among the complications portal hypertension (57%), hepatic encephalopathy(89.28%), hepatorenal syndrome (42.8%) among hyponatremia cirrhotic patients are statistically significant(p<0.05). child pughturcot score, MELD, MELD-Na score are also high in hyponatremia. Mortality also seen more in severe hyponatremia.
Conclusion: Dilutional hyponatremia is frequent in cirrhotic patients and associated with severe complications of liver cirrhosis like hepatic encephalopathy, hepatorenal syndrome. Hyponatremia is also associated with high morbidity and mortality in cirrhotic patients.
Keywords: Cirrhosis, Hyponatremia ,Child Pugh Turcot score, MELD,MELD-Na,