Title: New onset Refractory status epilepticus: a case report
Authors: Dr Ganesan Vivek, Prof. Dr Lailu Mathews, Prof. Dr K. Subramaniyan, Dr Sanjeev Kumar, Dr Maria Francis Roch.Y
Refractory status epilepticus is a neurological condition that follows a febrile illness. One variant of RSE is FIRES. Sequelae of FIRES include neuropsychological impairments occurring without latency. Clinical knowledge about FIRES is very scarce as it is rare manifestation. Patients usually present with prolonged period of refractive epileptic events which do not respond to first- and second-line anticonvulsant drugs. Though Few previously observed cases reported its association with autoantibodies, but no perticular antibody was found to be specific for the disease till now. Treatment of FIRES is difficult and it depends on the responsiveness of the patient to antiepileptic drugs along with anesthetics steroids and other supportive drugs. Mortality rate is high and few cases have reported relapses. early management is necessary in order to achieve control of the critically ill patient, control long term seizures and improve the quality of life of the patient.
Keywords: Immunity, Refractory status epilepticus, Febrile infection-related epilepsy syndrome (FIRES), Epilepsy, Seizure, Fever, Antiepileptics, Infection
FIRES is a serious neurological manifestation, that require early management of refractive seizures. Till now no specific diagnostic and management protocols were formalized. Aggressive treatment is required in the intensive care units to reduce the morbidity and mortality of the patient.