Title: Effect of Natural Polyphenols on Reactive Oxygen Species in Patients with Myocardial Infarction: A Double Blind Placebo Controlled Trial
Authors: Dr Rahul Goyal, Prof. S. Nagtilak, Prof. Vijay Thawani, Dr Shavetika Jindal
Introduction: Reactive Oxygen Species (ROS) and Reactive Nitogen Speices are lethal in nature. These leads to Oxidative stress. Oxidative stress stimulates the secretion of various cytokines and leukocyte adhesions to smooth vascular cells. This promotes the entry of Monocytes to sub-intimal space of coronary arteries. These Monocytes consumes Oxidized LDL particles and converts in to foam cells and leads to MI.
Material and Methods: A Pomegranate Extract of Whole Fruit (PEWF) was prepared as tablet of 300 mg to investigate its effects in synthesis of antioxidants and Antioxidative enzymes in patients with MI. Total 100 participants of either gender with nested cases of MI were included in present study. All participants were assigned in two groups (50 each). One group was under “Add On” therapy of PEWF and matching placebos of same colour, shape and size were used as comparator agent for second group (300 mg BD for 1 month).
Results: Results were compared by Z test, Chi square test and coefficient of variations. Statistical analysis proves the prognostic effect after active medication (p<0.05). Study results indicate the rejection of Null Hypothesis (H0) and acceptance of Alternative Hypothesis (H1).
Conclusion: Results highlighted that those participants who were under “add-on” therapy of PEWF showed high levels of Total Antioxidants and Antioxidative Enzymes in blood. This is a good sign of prognosis. Thus PEWF should be consumed in diet as food supplementation.
Keywords: Myocardial infarction, Coronary Artery Disease, Pomegranate Extract of Whole Fruit, Total Antioxidants Activity, Glutathione Reductase.