Title: Correlation between Her2/neu oncoprotein expression and prognostic factors in papillary thyroid carcinoma
Authors: Debahuti Mohapatra*, Debasmita Das, Anima Hota
Background: Thyroid cancer is one of the increasing cancers diagnosed in Western as well as Eastern countries. Papillary thyroid cancer (PTC) is the most common thyroid cancer. Few researches are done determining the role of Her 2/neu in PTC diagnosis as well as prognosis which have been contradictory to each other. Thus the present study is aimed at correlation of the Her 2/neu expression with various prognostic factors such as tumour size, different subtypes, multifocality, capsular involvement with extra-thyroidal extension and lymph node metastasis.
Materials and Methods: The study period was performed from January 2016 to December 2018 in pathology department of IMS and SUM hospital. Of total 83 total/subtotal thyroidectomy cases received, 25 cases were diagnosed as papillary carcinoma on haematoxylin and eosin histology sections. The detailed clinico-pathological parameters were noted in these patients and were further subjected to immunohistochemistry for Her 2/neu expression.
Results and Observations: In the study, female (60%) predominance was there and the age ranged from 14 years to 70 years. Majority of these tumours presented as solitary cold nodules but for 24% cases with multifocality. Total 7 cases (28%) showed Her 2/neu positivity (3+) and majority belonged to low risked group. Strong correlation was found between tumour size, multifocality and lymph node metastasis. No correlation was found with extra-thyroid extension or vascular invasion.
Conclusion: Variable Her2/neu positivity was seen in different variants of PTC as well as different clinical parameters
Study type and design: Hospital based cross sectional study and is an observational study.
Keywords: Her 2/neu, papillary thyroid carcinoma, thyroid neoplasm, prognosis.