Title: Evaluation of Serum Uric Acid Levels in Patients of Type- 2 Diabetes Mellitus, Attending in Tertiary Care Hospital at, NMCH, Patna
Authors: Dr Nayana Deb, Dr Santosh Kumar, Dr Satyendu Sagar
Objective: The present study was to evaluate the serum uric acid levels in patients of Type- 2 Diabetes Mellitus and its comparison with normal healthy adult individuals and to correlate serum uric acid levels with different glycemic levels in patients of Type- 2 Diabetes Mellitus.
Materials and Methods: A total of 42 patients with the different age, sex, dietary habits, drinking habits, predominant physical activities, BMI, socio-economic status having fasting blood glucose level >126 mg/dl and diagnosed patient of DM either on hypoglycemic drugs or insulin were also included in the study group. A total of 42 non- diabetics individuals were selected from attendants of patients, hospital staffs, by matching the age and other aspects to the study group as control group. Estimation of Fasting blood glucose level, HbA1c level, Serum Uric acid level were done by Hexokinase methods, D-10 micro column methods, and by uricase method respectively.
Results: The mean serum uric acid level in Group A, Group B and Group C were 5.85 mg/dl with a range of 4.3-8.6 mg/d1, 6.26 mg/dl with a range of 1.7-7.5 mg/d1 and 6.32 mg/ dl with a range of 3.5-8.9 mg/dl respectively. Serum uric acid level of subjects of type-2 DM with HbA1c <7when compared to control subjects with HbA1 c <7 showed higher values. The mean serum uric acid level was 5.26mg/dl range of 4.3-6.8 mg/dl in subjects of type- 2DM groups and 3.93 mg/dl with a range of 2.2-6.7 mg /dl in control groups.
Conclusion: Uric acid is a last by product of purine metabolism and its increased levels have been associated with insulin resistance and in Type-2 Diabetes Mellitus. The relation between Type-2 DM and increased serum uric acid level has been observed. Randomized controlled trial is needed to see whether lowering serum uric acid level decreases the glycemic level of the DM patients or not.
Keywords: Glycated Hemoglobin, Fasting Blood Sugar, Diabetes Mellitus, Uric acid.