Title: Hematological Parameters of Patients Suffering from Megaloblastic anemia and Aplastic anemia, Attending in Tertiary Care Hospital at Betiah, West Champaran, Bihar
Authors: Dr Sudhendra Nath Sinha, Dr U.S.Pandey, Dr A. Rai
Objective: The present study was undertaken to evaluate the role of red cell indices in differentiation between macrocytosis of aplastic anemia and megaloblastic anemia.
Materials and Methods: A total of 36 patients each of bone marrow biopsy proven, megaloblastic anemia and aplastic anemia were included in the study. From all the patients of both the group’s CBC were done by fully automated, five part CBC machine supplied by Mindray. All the parameter was noted and comparative study were evaluated.
Results: It was observed that MCV was greater than 97 fl. in 14 cases of aplastic anemia (Mean MCV 106.8 fl) and 22 cases of megaloblastic anemia (mean MCV 111.82 fl). Hb, MCV, and MCHC were comparable in the two groups. However mean RDW (Red cell width) in megaloblastic anemia (mean 86.8 fl) was significantly higher than those in aplastic anemia (mean 70.4 fl). The difference in RDW of patients with megaloblastic anemia and aplastic anemia was statistically significant.
Conclusion: RDW can be of help to differentiate between the megaloblastic anemia and aplastic anemia.
Keywords: Mean corpuscular volume (MCV), Macrocytes, Red cell distribution width (RDW), MCHC, HB.