Abstract
Objectives: Hypothyroidism is one of the commonest endocrine disorders. Autoimmunity has an important role in its etiology. The immunomodulatory role of vitamin D is emphasized in recent years. Vitamin D insufficiency/deficiency is seen to be associated with many autoimmune diseases like multiple sclerosis, SLE, Type 1 DM etc. This study was aimed to see the relation between serum vitamin D levels and serum TPO Ab levels in hypothyroid disease.
Materials and Methods: Serum vitamin D (25-OH) levels were measured in 25 patients with autoimmune positive hypothyroidism and 27 healthy subjects, utilizing the ELISA method (Calbiotech diagnostics, USA). Vitamin D deficiency was designated at levels lower than 20 ng/ml. Antithyroid peroxidase antibodies were assayed by ELISA. TSH, T3, T4 levels were evaluated in all patients.
Results: Serum 25(OH)D was significantly lower in hypothyroid patients [median value with interquartile range-14.3(12.65-17.90)] than in controls [median value with interquartile range- 26(21-32.8)]. Serum 25(OH)D values has shown weak inverse correlation with TPOAbtitres.
Conclusion: The results of this study showed vitamin D deficiency in autoimmune hypothyroidism. The weak correlation between vitamin D and TPO Ab indicates the association but to prove it more extensive studies are required.
Keywords: Vitamin D; Hypothyroidism; TPO Ab; Thyroid autoantibodies, Autoimmune hypothyroidism.
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DOI: http://dx.doi.org/10.18535/jmscr/v4i2.57
