Abstract
Aim: To compare macular and peripapillary RNFL thickness in amblyopic & fellow eye in unilateral amblyopia,using OPKOS SLO/OCT.
Method: A prospective cross sectional study was conducted on 55 patients (37 anisometropia,10 strabismic & 7 form deprivation) of 5-40y of age(mean 20.2±8.4).Macular and RNFL thickness were measured using SD-OCT(OPKOS SLO/OCT) and compared.
Result: Mean macular thickness of all amblyopia patients showed statistically significant increase (P=0.05) in amblyopic eye( AE=262.27±19.29,Non AE=255.21±18.63).On subgroup analysis, increase was significant only in anisometropes (P=0.03)while RNFL thickness was increased in strabismic amblyopes (P=0.04).(AE=102.22±14.06 Non AE=93.55±12.24).No correlation was found with age of patient.
Conclusion: There was a significant increase in mean macular thickness in 55 amblyopes,which was significant only in anisometropes, while RNFL thickness was significantly increased only in strabismic amblyopia, when compared with fellow eye. These results corroborate with findings of similar previous studies.
Keywords-amblyopia, macular thickness, RNFL ,SD-OCT
References
1. Ganekal S, Jhanji V, Liang Y, Dorairaj S.Ophthalmic Epidemiol. 2013 Aug; 20 (4):228-31. doi: 10.3109/09286586.2013.809772 Prevalence and etiology of amblyopia in Southern India: results from screening of school children aged 5-15 years.
2. Baddini-Caramelli C., Hatanaka M., Polati M. Thickness of the retinal nerve fiber layer in amblyopic and normal eyes: a scannig laser polarimetry study. J. AAPOS.2001;5:82–84. [PubMed]
3. Dyer D, Bierman Eo.Am J Ophthalmol. 1952 Jan;35(1):66-8.Cortical potential changes in suppression amblyopia.
4. Provis J.M., van Driel D., Billson F.A., Russell P. Human fetal optic nerve: overproduction and elimination of retinal axons during development. J. Comp. Neurol. 1965;238:92–100. [PubMed]
5. Schuman J.S., Pedut-Kloizman T., Hertzmark E. Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Ophthalmology.1996;103:1889–1898.
6. Yoon SW, Park WH, Baek SH, et al. Thicknesses of macular retinal layer and peripapillary retinal nerve fiber layer in patients with hyperopic anisometropic amblyopia. Korean J Ophthalmol 2005;19:62e7.
7. Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci 2004;45:2224e30.
8. Christiane E Al-Haddad, Georges M EL Mollayess, Carol G Cherfan, Br J Ophthalmol published online March 11, 2011 .Retinal nerve fibre layer and macular Dalida F Jaafar and Ziad F Bashshur
9. Huynh SC, Samarawickrama C, Wang XY, et al. Macular and nerve fiber layerthickness in amblyopia: the Sydney Childhood Eye Study. Ophthalmology 2009;116:1604e9.
10. Altinas O, Yuksel N, Ozkan B, et al. Thickness of the retinal nerve fiber layer, macularthickness, and macular volume in patients with strabismic amblyopia. J Pediatr Ophthalmol Strabismus 2005;42:216e21.
11. Repka MX, Cohen NG, Edwards AR. Retinal nerve fiber later thickness in amblyopic eyes. Am J Ophthalmol 2006;142:247e51.
12. Kee SY, Lee SY, Lee YC. Thickness of the fovea and retinal nerve fiber layer in amblyopia and normal eyes in children. Korean J Ophthalmol 2006;20:177e81.
13. Von Noorden GK. Classification of amblyopia. Am J Ophthalmol 1967;63:238e44.
14. Park KA, Park DY, Oh SY. Analysis of spectral-domain optical coherence tomography measurements in amblyopia: A pilot study. Br J Ophthalmol 2011;95:1700-6.
15. Agrawal S, Singh V, Singhal V. Cross-sectional study of macular thickness variations in unilateral amblyopia. J Clin Ophthalmol Res 2014;2:15-7.
16. Elvan Yalcin and Ozlem BalciClin Ophthalmol. 2014; 8: 749–753.Published online 2014 Apr12. doi: 10.2147/ OPTH.S58541 PMCID: PMC3990465Peripapillary retinal nerve fiber layer and foveal thickness in hypermetropic anisometropic amblyopia
17. Walker RA, Rubab S, Voll AR, Erraguntla V, Murphy PH.Can J Ophthalmol. 2011 Oct;46(5):425-7. doi: 10.1016/j.jcjo.2011.07.013. Epub 2011 Aug 4.Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia.
18. Quoc EB, Delepine B, Tran TH. Thickness of retinal fiber layer and macular volume in children and adults with strabismic and anisometropic amblyopia. J Fr Ophtalmol 2009;32:488e95.
19. Ozkok A,Akkan JCU,Tamcelik N,Erdogan M,Comlekoglu DU,Yildirim R.Comparison of retinal nerve fiber layer and macular thickness measurements with Stratus OCT and OPKO/OTI OCT devices in healthy subjects.Int J Ophthalmol 2015;8(1) :98103,doi: 10.3980/j.issn. 2222-3959.2015.01.18
20. Won Kyung Song,Sung Chul Lee, Eun Suk Lee, Chan Yun Kim, and Sung Soo Kim,Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain–Optical Coherence Tomography Study IOVS, August 2010, Vol. 51, No. 8