Title: NSAIDs and Renal function in Rheumatoid Arthritis
Author: Soobia Karim Ansari
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.51
Non-steroidal anti-inflammatory drugs(NSAIDs) are of the most commonly prescribed drugs in Rheumatoid Arthritis(RA).Their use carries a high risk of gastrointestinal and renal side effects. It is often difficult to differentiate between damage due to disease activity and that due to drugs (NSAIDs) used to treat rheumatoid arthritis. Although there are a number of parameters to study renal function, these cannot be applied to day to day practice and still remains research tools. In such a scenario, it is important to periodically monitor serum urea, serum creatinine and ESR, so as to pick up the earliest signs of inflammation and renal dysfunction in rheumatoid arthritis. For the above study 100 RA patients were enrolled, 50 being on NSAIDs. Elevated values i.e.S. urea (101.1%), S.creatinine (164.1%) and ESR (287%) was found in these subjects, which is statiscally significant. Treatment with Non-steroidal anti-inflammatory drugs (NSAIDs), showed decrease levels but it was not statistically significant. Hence, it is concluded from the above observation, that-raised levels of serum urea and serum creatinine is associated with rheumatoid arthritis and this in turn with variety of kidney disorders, principally due to chronic inflammation and drug exposure or toxicity. Keywords-Urea, Creatinine, RA, NSAIDs, ESR.
Abstract
