Oral Submucous Fibrosis- A Review on Clinical Presentation, Histology, Epidemiology, Aetiology, Pathogenesis, Malignanat Potential and Management

Title: Oral Submucous Fibrosis- A Review on Clinical Presentation, Histology, Epidemiology, Aetiology, Pathogenesis, Malignanat Potential and Management

Authors: Dr Girish Aggarwal, Dr Rajesh Bansal, Dr Vandana Chabbra, Dr Gourav Popli, Dr Sangeet Sethi, Dr Ankita Khatri

DOI: http://dx.doi.org/10.18535/jmscr/v4i2.17

Abstract

References

Corresponding Author

Abstract

Oral submucous fibrosis (OSMF) is a chronic, devastating disease characterised by juxtaepithelial fibrosis of the oral cavity. ⁽¹⁾Oral submucous fibrosis (OSMF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSMF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSMF is a diagnosis based on clinical symptoms and is confirmed by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved ⁽²⁾. We review and discuss all OSMF, including the terminology, presentation, aetiology, and pathogenesis, and provide a brief overview of its conservative and surgical management.

KEYWORDS- Oral Submucous Fibrosis, Epidemiology, Aetiology, Pathogenesis, Clinical Presentation, Management.

References

1. Arakeria G, Brennan PA. Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management. Br J Oral Maxillofac Surg 2013; 51: 587–593

2. Wollina U, Verma SB, Ali FM, Patil K. Oral submucous fibrosis: an update. Clinical, Cosmetic and Investigational Dermatology 2015:8

3. Pindborg JJ, Sirsat SM. Oral submucous fibrosis. Oral Surg Oral Med Oral Pathol 1966; 22:764–79

4. Selvam np, Dayanand AA. Lycopene in the management of oral submucous fibrosis. Asian J Pharm Clin Res, 2013; 6: 58-61

5. Angadi PV, Rao SS. Areca nut in pathogenesis of oral submucous fibrosis:revisited. Oral Maxillofac Surg 2011; 15:1–9

6. Pindborg JJ, Mehta FS, Gupta PC, Daftary DK. Prevalence of oral sub mucous fibrosis among 50915 Indian villagers. Br J Cancer 1968; 22: 646-54.

7. Khanna SS, Karjodkar FR. Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer: a randomised, controlled clinical trial. Head Face Med 2006; 2:33.

8. Sirsat SM, Pindborg JJ. Subepithelial changes in oral submucous fibrosis. Acta Path Microbial Scand 1967; 70:161-173.

9. Samdariya S, Kumar D, Kumar A, Porwal P, Pareek P. Oral submucous fibrosis – A short review. Int J Med Sci Public Health 2014; 3:1308-1312.

10. Angadi PV, Rao SS. Areca nut in pathogenesis of oral submucous fibrosis:revisited. Oral Maxillofac Surg 2011; 15:1–9.

11. Pillai R, Balaram P. Pathogenesis of oral submucous fibrosis: relationship to risk factors associated with cancer. Cancer 1992; 69:2011–20.

12. ChaudharyAK, Singh M, Singh M, Mehrotra R. Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis. Head & Neck Oncology 2009; 1-10

13. Sinor PN, Gupta PC, Murti PR, et al. A case control study of oral sub-mucous fibrosis with special reference to the etiologic role of areca nut.J Oral Pathol Med 1990; 19:94–8

14. Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, WarnakulasuriyaS. Oral submucous fibrosis: review on aetiology and pathogenesis. OralOncol 2006; 42:561–8.26

15. Jacob BJ, Straif K, Thomas G, et al. Betel quid without tobacco as a risk factor for oral precancers. Oral Oncol. 2004; 40(7):697–704.

16. Jeng JH, Tsai CL, Hahn LJ, Yang PJ, Kuo YS, Kuo MY. Arecoline cytotoxicity on human oral mucosal fibroblasts related to cellular thiol and esterase activities. Food Chem Toxicol. 1999; 37(7):751–756.

17. Kaur J, Rao M, Chakravarti N, et al. Co-expression of colligin and collagen in oral submucous fibrosis: plausible role in pathogenesis. Oral Oncol. 2001; 37(3):282–287.

18. Pandiar D, Shameena P. Immunohistochemical expression of CD34 and basic fibroblast growth factor (bFGF) in oral submucous fibrosis. J Oral Maxillofac Pathol. 2014; 18(2):155–161.

19. Tsai CH, Lee SS, Chang YC. Hypoxic regulation of plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts stimulated with arecoline. J Oral Pathol Med. Epub November 4, 2014

20. Avinash Tejasvi ML, Bangi BB, Geetha P, et al. Estimation of serum superoxide dismutase and serum malondialdehyde in oral submucous fibrosis: a clinical and biochemical study. J Cancer Res Ther. 2014; 10(3):722–725.

21. Hu Y, Jian X, Peng J, Jiang X, Li N, Zhou S. Gene expression profiling of oral submucous fibrosis using oligonucleotide microarray. Oncol Rep. 2008; 20(2):287–294.

22. Khan I, Kumar N, Pant I, Narra S, Kondaiah P. Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis. PLoS One. 2012; 7(12)

23. Chang YC, Hu CC, Tseng TH, Tai KW, Lii CK, Chou MY. Synergistic effects of nicotine on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts. J Oral Pathol Med. 2001; 30(8):458–464.

24. Baral R, Patnaik S, Das BR. Co-overexpression of p53 and c-myc proteins linked with advanced stages of betel- and tobacco-related oral squamous cell carcinomas from eastern India. Eur J Oral Sci. 1998; 106(5):907–913

25. Hsieh LL, Wang PF, Chen IH, et al. Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese. Carcinogenesis. 2001; 22(9):1497–1503.

26. Lee HC, Yin PH, Yu TN, et al. Accumulation of mitochondrial DNA deletions in human oral tissues – effects of betel quid chewing and oral cancer. Mutat Res. 2001; 493(1–2):67–74.

27. Kaur J, Srivastava A, Ralhan R. Expression of 70-kDa heat shock protein in oral lesions: marker of biological stress or pathogenicity. Oral Oncol. 1998; 34(6):496–501.

28. Rajendra R, George B, Sivakaran S, Narendranathan N. Visceral organ involvement is infrequent in oral submucous fibrosis (OSF). Indian J Dent Res. 2001; 12(1):7–20.

29. Lee SS, Tsai CH, Ho YC, Yu CC, Chang YC. Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Dis. 2012; 18(7):713–719.

30. Tung CL, Lin ST, Chou HC, et al. Proteomics-based identification of plasma biomarkers in oral squamous cell carcinoma. J Pharm Biomed Anal. 2013; 75:7–17.

Abstract

References

Corresponding Author

Call For Paper Volume 12 Issue 10 November 2024

JMSCR Menu

Impact Factor SJIF 2024: 7.892

Crossref - DOI

Editorial Policy

Frequency of Publication

Submission of Articles

Search