Abstract
The risk factors of pancreatic carcinoma was poorly understand, especially in our country as there were no proper studies done in our country. The main purpose of this study to know the risk factors of pancreatic carcinoma in rural India.
OBJECTIVES - There are many well established risk factors for pancreatic carcinoma like chronic pancreatitis, diabetes mellitus, tobacco smoking and alcohol consumption. We have studied the independent effects of these multiple risk factors for pancreatic carcinoma.
METHODS – We conducted a case control study involving 40 patients with clinically diagnosed pancreatic carcinoma and 40 frequency matched controls.
RESULTS – Chronic pancreatitis, diabetes mellitus, tobacco smoking and alcohol consumption were significant risk factors for the pancreatic carcinoma. Approximately 42.5%, 62.5%, 60%, 55% of pancreatic carcinoma patients in this study were belong to chronic pancreatitis, diabetes mellitus, smoking and alcohol respectively. The risk of developing pancreatic carcinoma in chronic pancreatitis, diabetes mellitus, tobacco smoking was 5, 3.5, 5, and 5 respectively. By multivariate analysis of binary logistic regression chronic pancreatitis and diabetes mellitus were found to be the risk factors of pancreatic carcinoma.
CONCLUSIONS – chronic pancreatitis, diabetes mellitus, tobacco smoking and alcohol consumption (>60ml ethanol/day) are proven to be the most established risk factors for pancreatic carcinoma.
Keywords-Pancreatic carcinoma, Risk factors, Chronic Pancreatitis, Diabetes Mellitus, Alcohol, Tobacco Smoking
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DOI: http://dx.doi.org/10.18535/jmscr/v4i2.05
