Abstract
Background: Thyroid disorders are among the most common endocrine disorders in India. The prevalence and pattern of the thyroid disorders depends on age, sex, geographical factors, food habits and on iodine intake.(1) A Hospital based case-control study was planned, including 50 patients of clinically proven hyperthyroid disease women patient (Case) and 50 age and sex matched controls attending medicine OPD and microbiology department of S. P. Medical College and Associated Group of Hospitals, Bikaner for study of Homocysteine, Folate and Cobalamine levels.
Method: Plasma Homocysteine, Folate and Cobalamine levels were measured by HPLC (High Performance Liquid Chromatography) Method in clinical Biochemistry laboratory, S. P. Medical College, Bikaner.
Results: A statically significant decreased concentration of plasma homocysteine was recorded in hyperthyroid patients as compared to Controls (p-value 0.0001). The serum vitamin B9 (folic acid) concentration was found to be decreased significantly in hyperthyroid female patients as compared to Controls (p-value 0.0001). A statically significantly increased concentration of serum cobalamine ( Vit B12) was found in hyperthyroid patients as compared to normal control female subject (p-value 0.0001).
Conclusion: Estimation of Serum Homocysteine, Folate and Cobalamine level is simple, reliable, economic and sensitive and it can be used in the proper management of developing new therapeutic strategies in treatment of hyperthyroid women patients.
Keywords: Homocysteine, Folate, Cobalamine, Hyperthyroidism.
References
1. Nimmy N.J, Annesh P.M. et al "A survey on the prevalence of thyroid disorder induced by demography and food habits in south. India population" 2012.
2. Dario M. Torre, Geoffrey C. Lamb, Jerome Van Ruiswyk: Kochar's Clinical Medicine for Students. pp.402-403: Lippincott Williams & Wilkins; Fifth edition (2008) ISBN 0-7817-6699-0
3. "Floyd, J.L. (2009) Thyrotoxicosis. eMedicine"
4. Heineke J.W.Rosen., H.Suzuki L.A. and Chait A.role of sulfur containing amino acid in superoxide production and modification of LDL.J.Bio.chem.(1987) 262:10098-10103.
5. Mccully K.S. and Carvaloh, A.C Homocystiene,thiolactone homocystiene thiolactonyl retinamide and platelet aggregation-Res.communi. chem. Pathopharmacolgy(1987) 56:349: 360.
6. "Depression and Psychosis in Neurological Practice.".Bradley's neurology in clinical practice. (6th ed.). Philadelphia, PA: Elsevier/Saunders. 2012. p. 102-103 Chan WB, Yeung VT, Chow CC, So WY, Cockram CS. (1999). "Gynaecomastia as a presenting feature of thyrotoxicosis". Postgrad Med J. 882 (75): 229–31. PMC 1741202. PMID 10715765.
7. Janet E. Hall, Lynnette K. Nieman: Handbook of diagnostic endocrinology, pp. 124-125
8. Anna Orzechowska- Pawilojc, Krzysztof Sworczak et al "Homocysteine, folate and cobalamin levels in hyperthyroid women before and after treatment 2007; 54(3): 471-6.
9. Gyftaki H, Kesse-Elias M et al “Serum vitamin B12 and folic acid levels in hyperthyroidism’’Nuklearmedizin. 1979; 18 (6):278-82.
10. Dermirbas B, Ozkaya M et al "Plasma homocysteine levels in hyperthyroid patients" Endour J 2004 Feb; 51 (1): 121-125.
11. Lien EA, Aakvaag A et al" Plasma total homocysteine levels during short terms iatrogenic hypothyroidism." 2000; 85:1049-1053.
12. Gyftaki H, Kesse-Elias M et al “Serum vitamin B12 and folic acid levels in hyperthyroidism’’Nuklearmedizin. 1979; 18 (6):278-82.
13. Nedrebo BG, Ericsson UB et al “Plasma total homocysteine levels in hyperthyroid
Andhypothyroid patients’’Metabolism. 1998 Jan; 47(1):89-93.
14. Bjorn G.Nedrebo ,Ottar Nvgard et al “Plasma total Homocysteine in hyperthyroid and hypothyroid patients before and during 12 months of Treatment’’2001.
Corresponding Author
Rohitash Kumar
M.Sc. (Medicine) Biochemistry, Senior Demonstrator, Department of Biochemistry,
SMS Medical College, Jaipur, Rajasthan (INDIA)
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mob: - 09602695338
DOI: http://dx.doi.org/10.18535/jmscr/v4i3.23
