Study of Cognitive Impairment in Type 2 Diabetes Mellitus

Title: Study of Cognitive Impairment in Type 2 Diabetes Mellitus

Authors: Supriya Barsode MD, Vaibhav Lotake MD, Arundhati Diwan MD, Kaustubh Shendker, Paras Doshi, Rakesh Patil

DOI: http://dx.doi.org/10.18535/jmscr/v4i6.37

Abstract

References

Corresponding Author

Abstract

An observational and cross-sectional study was undertaken. 50 Diabetes Mellitus patients and 50 age and sex matched controls between 40 to 60 years of age in Bharati Hospital and Research Centre, Pune over a period of 2 years. The aim was to study the cognitive impairment in patients of Type 2 Diabetes Mellitus. The objective being to study and assess the association between the type 2 Diabetes Mellitus ,the role of comorbidities associated with Type 2 Diabetes Mellitus and the duration of Type 2 Diabetes Mellitus and incidence of cognitive impairment and executive dysfunction.

The study has shown that people suffering from Diabetes Mellitus have statistically increased reaction time and also have decreased executive functions as compared to non Diabetic population. MMSE scores in Diabetics was not statistically significant, hence we can concluded that diabetics do not have moderate to severe cognitive impairment. The duration of Diabetes Mellitus, presence of other comorbidities did not affect cognition in Type 2 Diabetes Mellitus in our study.

Patients suffering from Type 2 Diabetes Mellitus should be regularly screened for cognitive impairment for early detection and prevention of progression of cognitive impairment.

Keywords: Diabetes Mellitus, Cognitive impairment, executive function, comorbidities.

References

1. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20:1183-1197.

2. L Kataria, H Pandya, S Shah, H Shah, R Gerg. Prevalence and pattern of cognitive dysfunction in type 2 Diabetes Mellitus. International Journal of Medical and Applied Sciences 2013;2(4):245-252.

3. Tiwari SC, Tripathi RK, Farooqi SA, Kumar R, Srivastava G, Kumar A. Diabetes Mellitus: A risk factor for cognitive impairment amongst urban older adults. Ind Psychiatry J 2012;21:44-8.

4. Garcia- Casares N, Jorge RE, Garcia-Ames JA, Acion L, Berthier ML, Gonzalez-Alegre P,Nabrozidis A, Gutierrez A, Ariza MJ, Rioja J, Gonzalez-Santos P. Cognitive Dysfunctions in Middle-Aged Type 2 Diabetic Patients and Neuroimaging Correlations: A cross sectional study. J Alzheimers Dis. 2014 Jan 1; 42(4):1337-46.

5. van Elderen SG, de Roos A, de Craen AJ, Westendorp RG, Blauw GJ, Jukema JW, Bollen EL, Middelkoop HA, van Buchem MA, van der Grond J. Progression of brain atrophy and cognitive decline in DM: a 3 year follow up. Neurology. 2010 Sep 14; 75(11):997-1002.

6. Croxson SC, Jagger C. Diabetes and cognitive impairment: a community-based study of elderly subjects. Age Ageing. 1995 Sep; 24(5):421-4.

7. Karan, NS. Assessment of the cognitive status in diabetes Mellitus. J Clin Diagn Res. 2012 Dec; 6(10):1658-62.

8. Alencar RC, Cobas RA, Gomes MB. Assessment of cognitive status in patients with type 2 diabetes through the Mini-Mental Status Examination: a cross-sectional study. Diabetol Metab Syndr. 2010 Jan 28; 2:10.

9. Dey J, Misra A, Desai NG, Mahapatra AK, Padma MV. Cognitive function in younger type II diabetes. Diabetes Care. 1997 Jan; 20(1):32-5.

10. Rouch I, Roche F, Dauphinot V, Laurent B, Antérion CT, Celle S, Krolak-Salmon P, Barthélémy JC. Diabetes, impaired fasting glucose, and cognitive decline in a population of elderly community residents. Aging Clin Exp Res. 2012 Aug; 24(4):377-83.

11. Macander M, Talarowska M, Galecki P, Moczulski D, Lewinski A. Selected diabetes control indicators and working memory efficacy. Neuro Endocrinol Lett. 2011; 32(4):518-25.

12. Sanz CM, Ruidavets JB, Bongard V, Marquié JC, Hanaire H, Ferrières J, Andrieu S. Relationship between markers of insulin resistance, markers of adiposity, HbA1c, and cognitive functions in a middle-aged population-based sample: the MONA LISA study. Diabetes Care. 2013 Jun; 36(6):1512-21.

13. Solanki RK, Dubey V, Munshi D. Neurocognitive impairment and comorbid depression in patients of diabetes Mellitus. Int J Diabetes Dev Ctries. 2009 Jul; 29(3):133-8.

14. Gluck ME, Ziker C, Schwegler M, Thearle M, Votruba SB, Krakoff J. Impaired glucose regulation is associated with poorer performance on the Stroop Task. Physiol Behav. 2013 Oct 2; 122:113-9.

15. Tchistiakova E, Anderson ND, Greenwood CE, MacIntosh BJ. Combined effects of type 2 diabetes and hypertension associated with cortical thinning and impaired cerebrovascular reactivity relative to hypertension alone in older adults. Neuroimage Clin. 2014 Jun 5; 5:36-41.

16. Petrova M, Prokopenko S, Pronina E, Mozheyko E. Diabetes type 2, hypertension and cognitive dysfunction in middle age women. J Neurol Sci. 2010 Dec 15;299(1-2):39-41.

Abstract

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Call For Paper Volume 12 Issue 12 December 2024

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