Serum Enzymes in Organophosphorous Poisoning

Title: Serum Enzymes in Organophosphorous Poisoning

Authors: K. N. Pujari, N.E. Pore, S. P. Jadkar

DOI: http://dx.doi.org/10.18535/jmscr/v4i6.15

Abstract

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Abstract

Organophosphorus compounds have been widely used for a few decades in agriculture for crop protection and pest control. In India Organophosphorus poisoning is the most common. Acetylcholinesterase is an enzyme that breaks down the neurotransmitter acetylcholine results in a lowered level of acetylcholine, and ultimately the termination of nerve impulses. Organophosphorous compounds covalently block the active site of serine residue of acetylcholinesterase this irreversible inactivation leads to an excess accumulation of acetylcholines in the peripheral and central nervous system causing cholinergic manifestations.

We have estimated the serum enzymes such as acetylcholinesterase, lactate dehydrogenase, creatine kinase, amylase and lipase in organophosphorus poisoning patients and healthy controls. We found significantly decreased acetylcholinesterase (p<0.001) and significantly increased lactate dehydrogenase, creatine kinase, amylase and lipase in patients with organophosphorus poisoning as compared to controls (p<0.001). Serum acetylcholinesterase level was estimated only at the time of admission. Daily estimation of acetylcholinesterase and amylase levels may provide more informative in prediction the prognosis or severity of poisoning and to monitor the effectiveness of therapy.

Key words: Acetylcholinesterase, Lactate dehydrogenase, Creatine kinase Amylase

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