Controversial Pathogen: Blastocystis hominis Prevalence from Patients Attending a Tertiary Care Hospital Lucknow

Title: Controversial Pathogen: Blastocystis hominis Prevalence from Patients Attending a Tertiary Care Hospital Lucknow

Authors: Taiyaba, Malay Banerjee, Farhat Tahira, Mohammad Azam, Devendra K Niranjan

DOI: http://dx.doi.org/10.18535/jmscr/v4i8.57

Abstract

References

Corresponding Author

Abstract

Blastocystis hominis (B. hominis) is one of the most common enteric parasite and a highly controversial protozoan parasite regarding its pathogenicity. It has been variably regarded as a commensal and as a pathogen. The aim of this study was to determine the prevalence of B. hominis in relation to sex and age. The purpose of this study was to get a clear idea about the existence of B. hominis in symptomatic patients and their pathogenic effect in absence of other known pathogen. The present study was conducted in the Department of Microbiology of a tertiary care Hospital in Lucknow, India. Samples were collected after taking informed consent. A total of 640 stool samples were examined microscopically Out of all the samples examined 139 samples were found to be positive for at least one parasite. Among them B. hominis was found in fecal material of 41 patients (29.4%). In the present study common symptoms associated with B. hominis infection were abdominal pain (100 %), diarrhea (78%), Nausea (65.8%), Loss of weight (43.9%), Vomiting (21.9%), Constipation (21.9%). All the 41(29.4%) patients were treated with metronidazole 250 to 500 mg BID for 5-7 days because of symptoms and the presence of B. hominis stool specimens. After 5-7 days of treatment, all patients became asymptomatic with stools negative for B. hominis on follow-up examinations.

KEYWORDS: B.hominis Pathogenicity, Controversial Protozoan Parasite.

References

1. Zierdt CH, Blastocystis hominis–past and future. Clin Microbiol Rev, 1991(1)61–79.

2. Zierdt CH, Donnolley CT, Muller J, Constantopoulos G, Biochemical and ultrastructural study of Blastocystis hominis. J Clin Microbiol, 1988(5):65–970.

3. Arisue N, Hashimoto T, Yoshikawa H, Nakamura Y, Nakamura G, Nakamura F, Yano TA, Hasegawa M, Phylogenetic position of Blastocystis hominis and of stramenopiles inferred from multiple molecular sequence data. J Eukaryot Microbiol, 2002 (1):42–53.

4. Tan KS, New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev, 2008(4) 39–665.

5. Silberman JD, Sogin ML, Leipe DD, Clark CG, Human parasite finds taxonomic home. Nature 1996, 380(6573):398.

6. Barilari, M. J., Blastocystis hominis (sic). Prensa Med. Argent. 1924(11):54-858.

7. Caderin C. C., El Blastocystis hominis como parasite patogeno del hombre. Rev. Med. Trop. Parasitol, 1937(3) 07-213.

8. Mazza S., Frecuencia del Blastocystis hominis en as deposiciones de diarreicos cronicos y su tratiminto apropriado. Prensa Med. Argen, 1922(9)60-463.

9. Sangiorgi G., Pathogenicity of Blastocystis hominis. Pathologica 1930(22) 73-176.

10. Kudo, R. R, Charles C, Protozoology, Thomas Publisher, Springfield 1977(3)1073-1074.

11. Miller, J. H T, The protozoaIn A. J. Braude, C. E. Davis, and J. Fierer, Infectious diseases and medical microbiology. The W. B. Saunders Co., Philadelphia, 1986(6)610-625.

12. Smith, J. W, and M. J. Bartlett A. Balows and W. J. Hausler, Diagnostic procedures for bacterial, mycotic and parasitic infections. American Public Health Association, Washington, D.C 1981(4) 1153 1174.

13. Moghaddam DD, Ghadirian E and Azami M, Blastocystis hominis and the evaluation of efficacy of metronidazole and trimethoprim/ sulfamethoxazole. Parasitol Res, 2005 (4): 273-275.

14. El-Shazly AM, Abdel-Magied AA, El-Beshbishi SN, El- Nahas HA, Fouad MA, Monib MS, Blastocystis hominis among symptomatic and asymptomatic individuals in Talkha Center, Dakahlia Governorate, Egypt. J Egypt Soc Parasitol. 2005(2): 653-66

15. Tenzel DJ, Boreham PF. Blastocystis hominis revisited. Clin Microbiol Rev. 1996(9)563–584.

16. Tan KS,New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev. 2008(1):639–665.

17. Cimerman S, Cimerman B, Lewi DS, Prevalence of intestinal parasitic infections in patients with acquired immunodefi-ciency syndrome in Brazil. Int J Infect Dis, 1999(4): 203-206.

18. Andiran N, Acikgoz ZC, Turkay S, Andiran F, Blastocystis hominis–an emerging and imitating cause of acute abdomen in children. J Pediatr Surg 2006, 41(8):1489–1491.

19. Levy Y, George J, Shoenfeld Y, Severe Blastocystis hominis in an elderly man. Journal of Infect 1996(1):57–59.

20. Leder K, Hellard ME, Sinclair MI, Fairley CK, Wolfe R, No correlation between clinical symptoms and Blastocystis hominis in immunocompetent individuals. J Gastroenterol Hepatol 2005, 20(9):1390–1394.

21. Tungtrongchitr A, Manatsathit S, Kositchaiwat C, Ongrotchanakun J, Munkong N, Chinabutr P, Leelakusolvong S, Chaicumpa W, Blastocystis hominis infection in irritable bowel syndrome patients. Southeast Asian J Trop Med Public Health 2004(3):705–710.

22. El-Shazly AM, Abdel-Magied AA, El-Beshbishi SN, El- Nahas HA, Fouad MA, Monib MS, Blastocystis hominis among symptomatic and asymptomatic individuals in Talkha Center, Dakahlia Governorate, Egypt.J Egypt Soc Parasitol. 2005(2): 653-66.

23. Selçuk KAYA1, Emel SESLİ ÇETİN1, Buket CİCİOĞLU ARIDOĞAN1, Salih ARIKAN1, Mustafa DEMİRCİ1 Pathogenicity of Blastocystis hominis, A Clinical Reevaluation Türkiye Parazitoloji Dergisi, 2007 (3): 184-18.

24. Doğan N, Prevalance of Blastocystis hominis in Bozan region. Turkiye Parazitol Derg, 1998(3):247-250.

25. S. M. HUSSAIN QADRI,* GHADEER A. AL-OKAILI, AND FOUAD AL-DAYEL, Clinical Significance of Blastocystis hominis, journal of clinical microbiology, 1989 (27) 2407-09.

26. Kain K, Noble MA, Freeman HJ, Barteluk RL, Epidemiology and clinical features associated with Blastocystis hominis infection. Diagn Microbiol Infect Dis 1987(8)235-44.

27. Grossman I, Weiss LM, Simon D, Tanowitz HB, Wittner M. Blastocystis hominis in hospital employees. Am J Gastro 1992(87)729-732

28. Markell EK, Udkow M, Blastocystis hominis: Pathogen or fellow traveler? Am J Trop Med Hyg 1986(35)1023-1026.

Abstract

References

Corresponding Author

Call For Paper Volume 12 Issue 10 November 2024

JMSCR Menu

Impact Factor SJIF 2024: 7.892

Crossref - DOI

Editorial Policy

Frequency of Publication

Submission of Articles

Search