Title: The Prevalence of Anti-Thyroid Peroxidase Antibodies among Patients with Thyroid Swelling with Reference to FNAC and Thyroid Hormones
Authors: Hanushraj. R, Sudharsan. S, Balasubramanian.S
DOI: http://dx.doi.org/10.18535/jmscr/v4i8.56
Objective: The aim of the present study was to define the prevalence of anti-thyroid peroxidase antibodies among patients presenting with thyroid swelling and to correlate with their thyroid hormone status (free T3, free T4 and TSH) and FNAC. Design: Cross-sectional study. Materials and methods: 30 persons with age above 13 years who presented with complaints of thyroid swelling to our outpatient department were included in our study. Tpo- Ab, free T3, free T4 and TSH were measured and FNAC of the thyroid gland was performed. Results: The prevalence of anti-TPO-Ab was 53.33% with a female to male ratio of 2.2:1. FNAC of our study population with raised anti-TPO-Ab titer showed 16.66% had colloid goiter, 26.67% had Hashimotos’s thyroiditis, 3.33% had Grave’s disease and 3.33% had multi nodular goitre. Of the total study population 40% were in euthyroid state, 26.67% were in hypothyroid state, 23.33% were in hyperthyroid state and 10% were in subclinical hypothyroid state. Conclusion: The prevalence of anti-TPO-Ab is higher in patients with thyroid swelling, suggesting thyroid autoimmunity as a risk factor for thyroid swelling. Most of the patients were in euthyroid state. Colloid goiter was the most common FNAC finding
Abstract
