A Study of Serum Uric acid levels as a Prognostic Marker in Acute Myocardial Infarction

Title: A Study of Serum Uric acid levels as a Prognostic Marker in Acute Myocardial Infarction

Authors: Dr Anu Daber, Prof. Dr N.D.Punjabi, Dr Amit Agarwal

DOI: http://dx.doi.org/10.18535/jmscr/v4i9.64

Abstract

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Abstract

The aim was to evaluate any significant correlation between elevated serum uric acid levels and prognosis of patients with acute myocardial infarction primarily short term mortality.

Methods- In this tertiary centre based prospective study 100 new cases of acute MI were divided into various subcategories using Killip classification .Serum uric acid levels were measured on day 0, 3 and 7.Serum uric acid and Killip class were compared on day 0,3 and 7 to assess the prognosis.

Results: Majority of the patients were in the age group of 51-60 years, who accounted for 37 cases i.e. 37% of total cases. In our study out of 100 patients 70 (70%) patients were males whereas 30 (30%) were female patients. Majority of patients (45%) had BMI in the range of 30-34.9 kg/cm² .49% patients were diabetics with 33 males and 16 females, and 41% were hypertensive with 27 males and 14 females. History of smoking was present in 59% patients . Previous history of stroke was observed in 6% patients with 4 males and 2 females. Mean uric acid level in patients on day 0 belonging to Killip class I was 4.4 mg/dl compared to 7.01 in Killip class II ,8.29 in Killip class III and 9.87 in Killip class IV. Mean serum uric acid levels on day 7 in patients with Killip class I is 4.67 and those with Killip class II is 6.62 mg/dl.Of the 100 patients, six expired during hospital stay and all 6 belonged to higher Killip class with serum uric acid levels in the highest quartile.

Conclusion- Hyperuricemia is an indicator of poor prognosis in acute MI. Serum uric acid can be used as a marker of short term mortality in acute myocardial infarction.

Keywords- Acute MI,Killip class, Serum uric acid,hyperuricemia, short term mortality,CVD.

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